biochemistry

Future Physician Targets Tropical Diseases in Ghana

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Kramer in the Centre for Research in Applied Biology
Rachel Kramer ’23 in the Centre for Research in Applied Biology (CeRAB) at UENR with Ankrah, Babae, Kramer and Rabi Baidoo from left to right.
Rachel Kramer in a classroom full of children
Kramer collecting samples from schoolchildren.
Rachel Kramer with four friends
Kramer and friends sharing a home-cooked meal by Ankrah during the “going-away party” they all threw for her at the end of the summer.

With the International Day of Women and Girls in Science on February 11, Kalamazoo College commonly celebrates the accomplishments of scientists such as Rachel Kramer ’23.

The day, first marked by the United Nations in 2015, encourages women scientists, and targets equal access to and participation in science for women and girls. Such a day is desired because U.N. statistics show that fewer than 30 percent of scientific researchers in the world are women and only about 30 percent of all female students select fields in science, technology, engineering or math (STEM) to pursue in their higher education. Only about 22 percent of the professionals in cutting edge fields such as artificial intelligence are women, and representation among women is especially low professionally in fields such as information and communication technology, natural science, mathematics, statistics and engineering.

Rachel Kramer comforting a child providing a blood sample
Kramer often found herself comforting community members like this child as they gave their blood samples for tropical disease research.
Rachel Kramer with NeTroDis Research team at the University of Energy and Natural Resources
Rachel Kramer ’23 stands with a NeTroDis Research team at the University of Energy and Natural Resources (UENR). From left to right in the bottom row are Dr. Kenneth Bentum Otabil, Kramer, Ms. Blessing Ankrah, and Theophilus Nti Babae. From left to right in the top row are Charles Addai and Emmanual Bart-Plange.
Kramer enjoying fresh Ghanaian coconut
Kramer enjoying fresh Ghanaian coconut after Sunday service.

However, Kramer—a biochemistry major with a concentration in community and global health and a minor in Spanish—is bucking that trend. She will attend the Western Michigan University Homer Stryker M.D. School of Medicine in July 2023. Plus, she completed 10 weeks of research last summer investigating health inequities in Ghana, Africa, while collecting data and researching Neglected Tropical Diseases (NTD’s) for her Senior Integrated Project (SIP).

The lead up to her SIP opportunity began two summers ago when she decided to get into volunteer work abroad through International Volunteer Head Quarters (IVHQ). At that time, she spent two weeks in Ghana, where she performed health care outreach by providing wound care to people in remote areas under the supervision of local health professionals.

Rachel Kramer stands with four other people
Kramer, the NeTroDis Team and their study clinician, Dr. Vera Darko (far right), on the far left meet the president of the regional hospital (middle) to inform him of their research.
Ankrah and Otabil introduce Kramer to UENR’s Dean of Science at UENR, Professor SF Gyasi
Ankrah and Otabil introduce Kramer to UENR’s Dean of Science at UENR, Professor SF Gyasi.
Rachel Kramer hugging Blessing Ankrah
Kramer and her host mother, Blessing Ankrah.

While she was there, she saw people with parasitic diseases which she later found out were considered to be NTD’s. Such diseases are of special interest to the Centers for Disease Control (CDC) and World Health Organization (WHO). In fact, the two organizations have a roadmap for eradicating NTD’s by 2030, which involves working with local researchers in endemic regions to collect data to inform policy to better protect and serve the people affected by NTD’s.  

“I saw children 5 years old and younger with these ulcers half an inch deep in their ankles and feet,” Kramer said. “It struck me and I knew that these things shouldn’t be happening.”

Even before returning to Michigan, Kramer knew she wanted to go back to Ghana and develop her SIP there as her way of helping to solve the health issues she witnessed. She just didn’t know what might provide that opportunity.

Rachel Kramer standing with her SIP
Kramer in front of Kalamazoo College’s Dow Science Center, holding her 101-page SIP just before turning it in.
Tropical disease researchers pack into a van
Kramer and UENR students and staff packed into vans like this with all their gear to travel to fieldwork destinations.
What tropical disease researchers see under a microscope
A microscopic view of a participant sample.

After several random conversations asking people, including K alumni, about anyone doing research there, Kramer reached out through Twitter to Blessing Ankrah, a researcher with the NeTroDis Research Group, a non-governmental agency at the University of Energy and Natural Resources (UENR) in Sunyani, Bono Region of Ghana.

“Two weeks later, she ended up responding and said she’d be happy to collaborate,” Kramer said. “We started talking on Zoom and WhatsApp, and she decided to have me work on a project where they were updating the prevalence rates of two neglected tropical diseases called schistosomiasis and soil-transmitted helminthiasis.”

People walking down a flooded dirt road
Terrain such as the one pictured were roads teams had to walk several miles on in order to reach some of the communities. This contributes to why diseases are considered neglected. They are difficult for researchers and health personnel to reach.
Researchers looking at books and forms to translate documents
Multilingual UENR students are seen translating the research forms from English to Twi so the community members, who speak Twi, could participate in the research.
Four at a birthday party
Kramer celebrating Doris Berkoh’s (professor of Biochemistry at UENR) birthday with other UENR Biological Science faculty and staff.

According to the CDC, schistosomiasis parasites live in some types of freshwater snails, and humans become infected when their skin touches contaminated water. Health-care professionals diagnose schistosomiasis through urine and stool samples. Within days of becoming infected, patients typically develop a rash or itchy skin. Fever, chills, cough and muscle aches can begin within a month or two of infection. If left untreated, this disease can become fatal.

Soil-transmitted helminthiasis, the CDC says, targets human intestines as parasites’ eggs are passed in feces. If an infected person defecates outside—near bushes, in a garden or on a field, for example—parasitic eggs are deposited on soil. People can ingest the parasites when they eat fruits and vegetables that have not been carefully cooked, washed or peeled. Some infections can cause a range of health problems, including abdominal pain, diarrhea, blood and protein loss, rectal prolapse, and slowed or stunted physical and cognitive growth. Similar to schistosomiasis, if untreated, this disease can become fatal.

Group photo at Mole National Park
Group photo of Kramer and the junior year biological science students on the field trip to Mole National Park
Rachel Kramer surrounded by children
Kramer celebrating Cultural Day at a local Montessori.
Rachel Kramer surrounded by community members
Kramer standing with members of a community NeTroDis researchers visited after watching them construct a hand-made xylophone with wooden planks, leaves and a hole in the ground.

Ankrah became a host mom to Kramer as both worked on the project to update and investigate the relevance, intensity and risk factors of schistosomiasis and soil-transmitted helminthiasis in selected rural and hard-to-reach communities in the Bono and Bono East regions of Ghana. The opportunity was funded by the Hough SIP Grant and the Collins Fellowship through Student Projects Abroad (SPA) funding, both of which were through Kalamazoo College. .

“This summer was an experience where I was not only a researcher, but I was also a student and a family member,” Kramer said. “Blessing was able to show me what the food was like, what the people were like, what the culture was like and it was just an amazing life experience.”

Students at Mole National Park
Kramer with UENR students in the savanna on the field trip to Mole National Park.
Rachel Kramer looking through a microscope
Kramer in the Centre for Research in Applied Biology (CeRAB) at UENR microscopically analyzing samples.
Picking out clothes from a pile
Bringing clothes for community members during fieldwork visits.

Yet research definitely remained the purpose of her visit. For the first three weeks, it was necessary for the researchers to perform paperwork during business hours to ensure the ethical approval of the project by the Institutional Review Board (IRB) committees at UENR. During the evening hours, Ankrah introduced Kramer to her family and friends including host brother Lord Owusu Ansah; the university’s president, vice president and dean of science; and regional hospital leaders.

When the five-week field work began, Kramer and her fellow researchers traveled to eight isolated communities that had as few as five and as many as 200 residents to collect socio demographic and qualitative data along with urine and stool samples.

Four researchers walking down a dirt road
NeTroDis team walking on the dirt road to get to the communities. From left to right Theophilus Nti Babae, Otabil, Divine and Kramer.
Rachel Kramer in front of a tree with large roots
Kramer at one of the community sites for field work.
Rachel Kramer hugging Blessing Ankrah
Kramer with Ankrah for their daily “pre-work selfie.”

“We would get up at 4:30 a.m. and ride in a packed van for about three hours,” Kramer said. “When we arrived to the communities, many times we would have to walk a distance with all of our gear. Some of these communities were only a few households and are located so far from public roads, and that’s why these diseases are considered neglected. It took us two hours to walk to one of the communities on foot and there was no way to get there with a car. Since there are so few people living in these remote places, there’s no way the government would fund roads to these communities.”

After traveling back to the UENR campus from the field, the researchers stored their samples in freezers before resting for a few hours and then returning to the lab around 7 p.m. in the evening when they analyzed up to hundreds of samples. The immediacy was imperative despite their long days because the urine and stool samples would go bad within 24 to 48 hours.

Rachel Kramer with Kenneth Bentum Otabil
Kramer standing with her head researcher, Dr. Kenneth Bentum Otabil.
Rachel Kramer and the vice chancellor of UENR
Rachel Kramer exchanging a gift with the vice chancellor of UENR after introducing NeTroDis’s summer research project to him.
Rachel Kramer surrounded by children
Kramer with children at local market.

After the field work, Kramer’s biggest roles were inputting data, helping with the preparation of samples, and microscopic analysis of the specimens.

“Once we got our data from all eight communities, we compiled all of it and I worked with a data analyst at the university who helped me compile it to get our overall prevalence rates and associate the risk factors to the positive cases,” Kramer said.

This work became the basis for her SIP.

Short woman pats Kramer on her head
“This was the first time I met someone in Ghana who was older than me yet shorter and we had so much fun dancing together when I visited this community,” Kramer said.
Ghanian woman wearing colorful clothes provides a blood sample
A research participant dressed in beautiful Ghanaian clothing gives her blood sample for research.
Rachel Kramer hugging Blessing Ankrah
Kramer with Ankrah for their daily “pre-work selfie.”

“Now that my written SIP has been submitted, all that’s left to do is present my SIP at the annual Chemistry and Biochemistry SIP Symposium during the spring trimester and then wait to find out whether I attain honors from the faculty for my work,” Kramer said. “So many people questioned why I decided to do something so big for my SIP since I have already been accepted to medical school. But just because I have been accepted doesn’t mean I need to take a step back, so I decided to pursue a passion instead. I did this because I have seen these diseases firsthand and how disproportionately they affect people of low socio-economic status in tropical regions. I was emotionally driven to take part in the global movement to end the neglect. Additionally, I knew that this opportunity would enhance my cultural competence which can help me be a better physician to people in the future. Eventually, I’d like to be a study clinician in similar studies and even create the policies that can protect and serve people. With this foundational-level research under my belt, I am motivated to continue my research focus on NTD’s in medical school.”

And this might not be the last of her research outside of medical school.

“I’m still in contact with my host mom,” Kramer said. “I have a number of people in Ghana I text every week just to talk about various things like the projects they’re working on. Currently, they have two new projects that are going to be funded by the Bill and Melinda Gates Foundation regarding an NTD called Onchocerciasis, which is transmitted through biting black flies. I asked Blessing if it is possible for me to work remotely while I’m in medical school on those projects, and she said I probably could, but it is also possible that I could go back to Ghana during this upcoming summer to join their new projects in projects in person. Overall, I loved being abroad and how it opened up my eyes to the world and cross-cultural differences. Being a future physician, I was introduced to the atrocities of Neglected Tropical Diseases and I saw just how invaluable being a part of the team that is working to end the neglect really is.”

Science Society Honors K Professor with Teaching Award

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Regina Stevens-Truss Holds a Test Tube While Teaching Two Students for Science Society Award
Regina Stevens-Truss will receive the 2023 American Society for Biochemistry and Molecular Biology Award for Exemplary Contributions to Education.

Regina Stevens-Truss, Kalamazoo College’s Dorothy H. Heyl Professor of Chemistry and Biochemistry, is the recipient of the 2023 American Society for Biochemistry and Molecular Biology (ASBMB) Award for Exemplary Contributions to Education.

The ASBMB is a professional organization of science, one of the largest of its kind in the world. The award, instituted in 2005, credits an individual who encourages an effective teaching and learning of biochemistry and molecular biology while demonstrating a commitment to pedagogical engagement and teaching innovation. As one of 14 professionals from around the world being honored by the ASBMB, Stevens-Truss will give a presentation about her teaching and learning trajectory at the society’s 2023 annual meeting, Discover BMB, in March in Seattle.

“Being selected for this honor surfaces all of my humble bones,” Stevens-Truss said. “Never in my wildest dreams did I foresee being nominated and even less being selected for this award. My imposter syndrome persona is in full bloom right now, and I can hear all of the voices that tell me regularly ‘accept a compliment, Regina.’ This award means the world to me, I am honored and humbled, and can’t believe the list of pioneers that my name will be listed with.”

Stevens-Truss served on the Minority Affairs Committee (MAC), now known as the Maximizing Access Committee, as well as on the Education and Professional Development (EPD) Committee of the ASBMB, where she was part of the steering committee that created the concept-driven teaching strategies that laid the foundation for the organization’s certification exam. She also was the principal investigator in 2012 of a National Science Foundation grant that supported a STEM K-12 outreach initiative by the society called Hands-on Outreach to Promote Engagement in Science (HOPES – see pages 37-38 at this link).

Since joining the faculty at K in January 2000, Stevens-Truss has been teaching Chemical Reactivity, Biochemistry, Medicinal Chemistry and Infection: Global Health and Social Justice. Current research in her lab focuses on testing a variety of compounds (peptides and small molecules) for antimicrobial activity. She is also the College’s director of the Howard Hughes Medical Institute Inclusive Excellence grant, which was awarded to K’s science division in 2018. In 2016, she received K’s highest teaching honor, the Florence J. Lucasse Lectureship for Excellence in Teaching.

Stevens-Truss earned a bachelor’s degree from Rutgers University and a Ph.D. in medicinal chemistry from the University of Toledo. She held two fellowships at the University of Michigan between 1993 and 1999, one of which was a lectureship in medicinal chemistry.

“I joined the faculty at K in a department with the BEST team of educators and students that I could have asked for,” she said. “From day one, my chemistry and biochemistry department colleagues have supported every hair-brained idea I have come up with. They make me think hard about teaching by always keeping our students front-and-center in our conversations on this topic. My students have pushed me to be better, to care more, to guide them through their journey of learning and growth.  And, without all of these folks, this award would not have happened. This award is not just for me, but for all who have been in my life in the last 20-plus years. You know who you are!”

Signing Day Spotlights Students Headed to Graduate School

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Amanda Morrison Signing Day
Amanda Morrison ’22
Annie Tyler '22 Signing Day
Annie Tyler ’22

Bright careers await the seniors graduating soon from Kalamazoo College, including those in the Department of Chemistry and Biochemistry. Six of them were spotlighted recently during a Signing Day, featuring some of the scholars who are moving on to graduate programs this fall.

Much like student-athletes would gather to sign letters of intent when selecting their collegiate destinations, the chemistry students met to officially declare their educational next steps. The event was first envisioned by Subi Thakali ’21, Alex Cruz ’21 and Angela Ruiz ’21, who desired an academic answer to the accolades a student-athlete might receive during a Signing Day. Professor of Chemistry Jeff Bartz organized it that first year and even borrowed a photography backdrop from the athletics department.

Now, grad-school bound chemistry students from K receive some brief fame through social media as their pictures and destinations are featured in the department’s Twitter and Instagram accounts. Suja Thakali ’23, a leader in the Higher-Level Education in Dow student organization, planned much of this year’s event with Bartz again borrowing a backdrop. The students among the honorees on the Signing Day were:

Lia Schroeder
Lia Schroeder ’22
Grace McKnight on Signing Day
Grace McKnight ’22
  • Annie Tyler, who is heading to Yale University for a Ph.D. in organic chemistry
  • Amanda Morrison, who will join the University of Health Sciences and Pharmacy in St. Louis for a master’s degree in medicinal chemistry
  • Grace McKnight, who will attend the Grainger School of Engineering at the University of Illinois for a Ph.D. in theoretical and applied mechanics
  • Lia Schroeder, matriculating at Rutgers University for a Ph.D. in biophysical chemistry
  • Faith Flinkingshelt, moving on to the University of California-Irvine for a Ph.D. in inorganic chemistry
  • Ola Bartolik, who is seeking a Ph.D. in neuroscience from the University of Michigan.

The chemistry department expects the tradition to continue next year alongside students from the biology department. But for this year, Tyler’s destination is especially noteworthy as she will be the first Heyl scholar from K to be awarded a Heyl Fellowship in more than 15 years. Heyl scholars are high-achieving high school graduates from Kalamazoo County, who receive full-tuition scholarships to attend K in a STEM program or Western Michigan University’s Bronson School of Nursing. K grads who successfully matriculate to Yale are eligible to apply for the Fellowship.

Ola Bartolik
Ola Bartolik ’22
Faith Flinkingshelt
Faith Flinkingshelt ’22

Tyler—a chemistry and religion double major, Kalamazoo Central High School graduate and Kalamazoo Promise scholar—said Yale wasn’t a graduate school on her radar until she realized the possibility of attending on a Heyl Fellowship.

“When I visited the campus and chemistry building, Yale was the only place I visited where I didn’t have an ‘I like this, but here’s this issue I have with it’ feeling,” Tyler said. “I liked everything about it. I liked that it was in a new place, and that they seemed really excited about recruiting students. I could very easily picture myself at Yale for the next five years.”

The Heyl Fund will cover up to four years of Tyler’s tuition and fees along with a stipend in the Fellowship. For the upcoming academic year, those costs add up to more than $80,000.

“I’m really honored that I was chosen for the Heyl Scholarship and the Heyl Fellowship,” Tyler said. “The scholarship allowed me to attend Kalamazoo College in the first place. To see that my last four years of work at K have allowed me to become a Heyl Fellow makes me really proud and excited to continue the work.”

Chemistry Student Selected as National Science Foundation Graduate Research Fellow

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Portrait of National Science Foundation Graduate Fellow Ola Bartolik '22
Ola Bartolik ’22 has been selected by the National
Science Foundation as a Graduate Research
Fellow to support her graduate career at the
University of Michigan.

Ola Bartolik ’22 has been selected by the National Science Foundation (NSF) as a Graduate Research Fellow to support her graduate career at the University of Michigan.

Bartolik will graduate from Kalamazoo College in June with a bachelor’s degree in chemistry with a biochemistry concentration and a psychology minor. In August, she will begin a Ph.D. program at the University of Michigan, where she previously participated in research in the lab of Paul Jenkins for her Senior Integrated Project.

The National Science Foundation Graduate Research Fellowship Program (NSF GRFP) recognizes and supports outstanding graduate students in STEM disciplines who are pursuing research-based master’s and doctoral degrees at accredited U.S. institutions. The five-year fellowship includes three years of financial support, including an annual stipend of $34,000 and a cost of education allowance of $12,000 to the institution. The fellowship also provides access to opportunities for professional development.

Approximately 2,000 applicants are offered a fellowship from among more than 12,000 applicants per competition.

“I think it’s really important that students at K be aware of the fellowship,” Bartolik said. Bartolik said the application process offered experience in writing a research proposal and bolstered her grad school applications by showing she was already thinking about funding and research. While Bartolik had considered taking a gap year before entering graduate school, the combination of the fellowship offer with the community she has already found at the University of Michigan while working on her SIP proved irresistible.

“I was having a lot of doubt as to whether I could really put myself through a Ph.D. or whether I had the skills and the knowledge to do it,” Bartolik said. “If the National Science Foundation saw enough potential to invest in me, that makes me think I’m ready for grad school.

“When I posted the announcement on my academic Twitter, Paul Jenkins retweeted it, and the University of Michigan neuroscience program retweeted it, too. The head of the program emailed me that I should be really proud. I hadn’t even committed to graduate school yet and they were already celebrating with me.”

Bartolik was also quick to share the news with the chemistry department at K.

“We are very proud of Ola,” said Blakely Tresca, Roger F. and Harriet G. Varney Assistant Professor in the Department of Chemistry and Biochemistry. “This is an amazing accomplishment for an undergraduate student before starting a Ph.D. program. Ola is the first chemistry major in 25 years to earn this honor while still a student at K.”

Bartolik will earn her Ph.D. as part of the Program in Biomedical Sciences (PIBS) at the University of Michigan, an umbrella program that comprises a variety of research fields including neuroscience, pharmacology, biochemistry and more.

“I’m really interested in trying to combine either neuroscience and pharmacology, or neuroscience and chemistry, for designing new drugs or new molecules that could be used for research or for therapeutic purposes,” Bartolik said. “My goal has always been to combine chemistry with neuroscience because I like chemistry; I don’t want to let go of it. Neuroscience can be very bio-heavy and I feel like having a chemist’s perspective on biological systems like the brain is really valuable.”

While her graduate work in PIBS is funded, Bartolik said, research opportunities can be limited based on each lab’s available funding.

“The fellowship opens me up to more lab opportunities and makes it easier to secure a spot in a lab,” Bartolik said.

At this point, Bartolik is interested in possible careers with a pharmaceutical or biomedical company as well as the field of science communication.

“Something that’s been interesting to me more and more is science communication, and how to effectively communicate science to people who don’t have the background,” Bartolik said. “The SIP was good practice; even though it was to a chemistry major audience, I still had to explain how neurons work and why this research is important. I found that I like presenting; I don’t get as nervous as I used to. And I like to geek out about my work around neuroscience, so I think that’s something I want to explore more, opportunities in journalism or some sort of science communication.”

In addition to the professional affirmation and practical benefits, the award is personally meaningful to Bartolik.

“My father passed away in 2017 from a heart attack,” Bartolik said. “He always supported me in high school, in everything I did. And I feel like he would have been so proud of me. I felt him with me, celebrating. My parents left everything behind in Poland so my sisters and I could have a better life and more opportunities. I feel like I’m fulfilling that and trying to make the most out of the life I’ve been given.

“I feel like this is what I was meant to do.”

NSF has funded Graduate Research Fellowships since 1952. More than 70 percent of fellows complete their doctorates within 11 years, 42 fellows have gone on to become Nobel laureates, and more than 450 have become members of the National Academy of Sciences. Applications are generally due in October. For more information, visit the National Science Foundation website.

Lecture to Address Sustainable Energy Systems

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Luis M Campos to discuss sustainable energy systems
Columbia University Associate Professor of Chemistry Luis M. Campos

An associate professor of chemistry at Columbia University will speak at 7 p.m. Thursday, May 5, at Kalamazoo College’s Dalton Theatre about his research involving the creation of new materials that could reduce our carbon footprint and build sustainable energy systems.

Luis M. Campos’ talk, sponsored by the Chemistry and Biochemistry Department, is titled “Organic Materials Design for Next-Generation Energy Systems” and serves as the 2022 Tourtellotte Lecture. The lecture is open to the public. K visitors must provide proof of COVID-19 vaccinations including boosters, if eligible, at the door and in the form at hr.kzoo.edu/visitor. A dessert reception will follow at 8 p.m.

Campos grew up in Guadalajara, Mexico, until age 11 when he moved to Los Angeles. He received a bachelor’s degree in chemistry from California State University, Dominguez Hills in 2001, and a Ph.D. from the Department of Chemistry and Biochemistry at the University of California, Los Angeles in 2006. At UCLA, he was awarded the National Science Foundation Predoctoral Fellowship, the Paul and Daisy Soros Fellowship, and the Saul and Silvia Winstein Award for his graduate research in solid-state photochemistry.

Later working in materials chemistry, Campos went to the University of California, Santa Barbara as a UC President’s Postdoctoral Fellow. At Columbia, his group researches physical macromolecular chemistry. To date, he has co-authored more than 100 articles, has 13 patents and has been honored with several awards.

For more information about Campos and his research, visit the Campos Research Group website.

Chemistry Student’s Research Could Boost Antibiotics

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Chemistry Student Ola Bartolik Performing Research
Research conducted by Ola Bartolik ’22 at K has possible
implications for a new approach to antibiotics.

Ola Bartolik ’22 has an intrinsic curiosity about the importance chemistry plays in biology, specifically its role in neurodevelopment and neurological disease. Her high school interests in chemistry led her to apply for Kalamazoo College’s strong chemistry program, where she has been exploring the relationship between chemical structure and antimicrobial activity.

Her research in the lab of Blakely Tresca, assistant professor of chemistry, has possible implications for the development of new antibiotics, which is an urgent need in today’s medical field.

“There is an antibiotic crisis because we’re not finding new antibiotics and there is so much antibiotic resistance,” Bartolik said. “It’s becoming more and more of a problem as time goes by.”

Bartolik works with peptoids, which are man-made compounds similar to peptides, the building blocks of proteins. She is experimenting with adding different halogens to the peptoids to see how that changes the structure and if that plays a role in making the peptoid more anti-microbial.

Two years ago, Tresca saw in Bartolik the first two things he looks for in students—a spark of interest in organic chemistry and an excitement to make molecules in the lab—and invited her to join his lab. There, she discovered that she loves thinking about how research can lead to new questions, solve problems and apply to daily life.

“She has the drive to take ownership of a project and lead it in new directions,” Tresca said. “The project she’s working on right now is one she designed herself and has been leading, which is amazing even for a senior student.”

Bartolik is always prepared, able to work independently and thoughtful about science in both the lab and the classroom, Tresca said.

Ola Bartolik ’22 has worked in the research lab of Blakely Tresca,
assistant professor of chemistry, for two years.

“She is almost always the first person to jump up with an answer, which shows how much she’s thinking about what we’re talking about in class,” Tresca said. “I appreciate that she’s always willing to take a guess even if she’s not sure she’s right. They’re not easy questions and they’re things we don’t necessarily know the answer to, so it’s important to be comfortable with being uncomfortable and thinking through the science, which I really see with Ola.”

Tresca has been incredibly supportive in and out of the lab, Bartolik said, helping her apply to scholarships that have made her K experience possible.

“Ola has taught me as much as I’ve taught her, in terms of supporting students, helping them find opportunities and pursue those opportunities even if it’s something they feel like is a stretch,” Tresca said. “Ola is a fantastic person and a fantastic student. It’s been amazing working with her and I’m very excited to see what she does next.”

The support of both faculty and other students at K has been pivotal to Bartolik’s success. Her experiences at an all-girls high school were empowering as well. 

Bartolik values the open curriculum at K that has allowed her to choose only courses that interested her, which have ranged from chemistry and biology to literature and philosophy. Even in a sophomore seminar named Poetry as Survival, Bartolik found connections to her science interests as she considered the relationship between coping with difficult life experiences and stress-induced triggers of disease. 

“I always had this interest in neuroscience and how the brain works,” she said. “I was interested in the connection between chemistry and neuroscience and how it all works. I like looking at things on a smaller scale, a micro scale. If you change this one thing, what does it do to the whole system?”

For her Senior Integrated Project, Bartolik worked in the lab of Paul Jenkins at the University of Michigan. She investigated an epilepsy associated mutation and how it may impact critical protein-protein interactions necessary for neuronal signaling. 

Bartolik will graduate this year with a bachelor’s degree in chemistry with a biochemistry concentration and a psychology minor. She plans to attend graduate school to study neuroscience.

She is interested in studying the effects of environment and mutations on brain development and pathways, and the relationship between problems in those pathways and neurodegenerative diseases.

“Neuroscience programs are really hard to get into, especially when you don’t come from a neuroscience-heavy background with a lot of neuroscience research,” Bartolik said. “The fact that I even have options, I think that tells you how incredible the chemistry department is here and how we’re able to pursue things that don’t have to necessarily relate directly to what we did at K.”

New Biochemistry Major Formulates Student Options

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Biochemistry Professor Regina Stevens-Truss
Professor of Chemistry and Biochemistry Regina Stevens-Truss says the new biochemistry major at Kalamazoo College will provide an in-demand major for prospective students while better preparing current students for graduate programs.

Prospective students interested in science-based careers will have another reason to choose Kalamazoo College this fall. That’s when the Chemistry Department will offer both a chemistry and a biochemistry major. The new biochemistry major will expand the information addressed through the interdepartmental concentration currently offered at the College.

Biochemists commonly work in private industries, pharmaceutical and government labs, and higher education to increase the world’s understanding of the biological processes fundamental to life. At an undergraduate level, this field of study provides a foundation for graduate-level studies and careers in the health sciences such as medicine, veterinary medicine, dentistry, pharmacy, pharmacology and toxicology. This new major will open up these opportunities for our students as they prepare for careers beyond K.

Whatever the career path a science student follows, Professor of Chemistry and Biochemistry Regina Stevens-Truss said, “It’s our job to help them figure out what’s next for them after K, and a biochemistry major will help in that effort.

“Some students come to us thinking they know exactly what they want to do, but then they get here and discover biochemistry is fascinating,” Stevens-Truss said. “Those are the students I’m excited for most because this new major will offer us an opportunity to open up biochemistry for them. I’m excited for our students and I’m excited for our program.”

This major will require the core courses in chemistry (general, organic, analytical and physical chemistry), as well as the chemistry senior seminar course, Professional Development for Chemists. In addition, biochemistry majors will take interdisciplinary courses in biology, mathematics and physics, and either Cell and Molecular Biology or Biophysics, depending on their long-term goals and plans. The biggest benefit will come from the program adding three new biochemistry major-required courses to the chemistry department’s curriculum: a 300-level foundations of biochemistry course, a 400-level applications of metabolism course and a comprehensive research-style lab practicum.

“Up until now, chemistry majors interested in this field had been at a disadvantage in this area,” Stevens-Truss stated. “The biochemistry course currently required for the concentration (Chem 352) is a survey of biochemistry topics—there is just not enough time to immerse oneself into the subject. Important topics such as photosynthesis, cellular signaling and genetics, and gene cloning aren’t currently addressed in that course. We hope that students are exposed to those topics by taking the required biology courses needed for the current concentration.”

However, in going from K to a graduate or post-baccalaureate program or to a job, “students need to be able to think critically about the application of these topics to real-world issues, which the new major is poised to help them do” Stevens-Truss said.

Prospective students and families are encouraged to discuss their interests in the biochemistry major and the benefits of it further when they talk to Admission representatives and chemistry and biochemistry department faculty to get additional information and for seeking more opportunities.

“Everybody has probably heard that ‘chemistry is everywhere’, but we don’t always see it,” Stevens-Truss said. “This biochemistry major will give students opportunities to see it in everyday life. That’s the excitement. This is giving us opportunities to offer students coming to K a chance to say, ‘This stuff is really cool,’ because life is cool.”

Conference, Faculty Catalyze Chemistry Students

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The opportunity to present to and learn from pharmaceutical professionals is normally reserved for graduate students, professional scientists and postdoctoral fellows. For Kalamazoo College chemistry students in Dorothy H. Heyl Professor of Chemistry Laura Furge’s lab, attending the Great Lakes Drug Metabolism and Disposition Discussion Group annual meeting as undergrads is a tradition that opens doors and underscores their passion for science.

Chemistry Students Attend Drug Metabolism Conference
Three chemistry students attended the Great Lakes Drug Metabolism and Disposition Discussion Group on May 9 and 10 in Ann Arbor with Dorothy H. Heyl Professor of Chemistry Laura Furge (second from right). The students are Kevin McCarty ’20 (left), Cydney Martell ’19 (second from left) and Michael Orwin ’20 (right).

Three students attended the spring meeting on May 9 and 10 in Ann Arbor. Furge’s students, known for their research excellence, have had several opportunities in recent years to show off their work regarding the P450 enzyme, which catalyzes drug-metabolism reactions, with implications toward drug discovery.

This year’s K representatives included Cydney Martell ’19 of Gull Lake, Michigan; Kevin McCarty ’20 of Clarkston, Michigan; and Michael Orwin ’20 of Portage, Michigan.

“I feel I was really fortunate to get into (Furge’s) lab,” said Martell, whose connection with Furge also helped her secure an internship last year with Eli Lilly, a pharmaceutical company headquartered in Indianapolis and committed to discovering medicines for people around the world. “The most rewarding thing about the conference is our ability to network with individuals and build important relationships. It’s nice to be able to have that connection and be on equal ground. It’s a love of science that facilitates our ability to work across experience levels.”

Martell will seek a Ph.D. in biochemistry at Northwestern University beginning this fall.

The poster presentation McCarty made from his research in Furge’s lab will evolve into his Senior Individualized Project this summer, he said, which is a testament to Furge’s guidance.

“Instead of telling you how to do things, she’ll ask you questions, engaging you in the work,” McCarty said. “She gives you the freedom to do every part of the research you can by yourself, which helps you understand and take away what’s important.”

In fact, McCarty has been so happy with his experiences in the chemistry program at K, the drug-metabolism conference and in Furge’s lab, he’d tell prospective students considering K to also major in chemistry.

“I would tell them, ‘you’d be surprised by all the opportunities you’ll have,’” McCarty said. “When I first considered K, I heard all about our small class sizes and the faculty. What they didn’t tell me is how many opportunities there would be to work with faculty members like Dr. Furge or in a lab like hers.”

Orwin echoed his peers’ excitement for attending the conference and appreciation of Furge’s leadership in their lab at K.

“I really loved attending the conference and it was a great undergraduate experience being able to present my work to industry professionals,” Orwin said. “Overall, I find the most exciting part of research is the ability to contribute to our collective knowledge alongside being able to share one’s passion with others. I find myself very fortunate for being able to have this experience.”

Chemistry Symposium Bids Farewell to 40-Year Professor

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UPDATE: The venue for the chemistry symposium has been changed to Dewing Hall, Room 103.

Kalamazoo College department symposiums typically kick off student presentations of senior individualized projects. This year’s chemistry symposium has added significance, serving as the official sendoff for Dorothy H. Heyl Professor of Chemistry Tom Smith, who is retiring after 40 years at the College.

Chemistry Symposium Speaker Tom Smith
This year’s chemistry symposium has added significance, serving as the official sendoff for Dorothy H. Heyl Professor of Chemistry Tom Smith, who is retiring after 40 years at the College.

The chemistry symposium will start at 4:10 p.m. Thursday, April 18, 2019, in Dewing Hall, Room 103. Kalamazoo College President Jorge G. Gonzalez will welcome attendees before Interim Provost and Chemistry Professor Laura Furge introduces alumni Chris Bodurow and Bob Weinstein, both ’79. Bodurow and Weinstein were students in the first class Smith taught in the 1978-79 school year.

After the opening remarks, Smith will offer a lecture titled “Reflections on Teaching and Research in Inorganic Chemistry: From Small Molecules to Crystals to Metalloproteins.” A reception will follow at Dow Science Center.

“We have invited alumni to attend and send notes that we will present” to Smith, Furge said. “Alumni will continue to see how strong the Chemistry department is. All faculty are research active as campus is abuzz in summer with research students, and their grants and publishing show how deeply invested our faculty are in teaching pedagogies.”

Bodurow and Weinstein were a part of the fundraising effort that endowed a research fellowship in Smith’s honor. The Thomas J. Smith Student Research Fellowship in Chemistry honors Smith by supporting an initiative close to his heart: independent summer research.

“The endowment to fund student research positions is a very fitting tribute to the work [Smith] has done,” Furge said. “He has faithfully taken on at least two students each summer, committing himself to mentoring and influencing generations of students.”

Testifying to the devotion Smith has inspired, he was designated an Alpha Lambda Delta National Honorary Society Favorite Teacher by first-year students 13 times. In addition, he directed the senior individualized projects of 70 students, was named a Camille and Henry Dreyfus Foundation Scholar and was awarded the Florence J. Lucasse Fellowship for Excellence in Scholarship or Creative Work and the Dr. Winthrop S. and Lois A. Hudson Award for Outstanding Contributions in Research at Kalamazoo College.