The Magnificent Five

Five women representing Kalamazoo College
(Left to right) Regina Stevens-Truss, Lindsey Gaston, Sandrine Zilikana, Laura Lowe Furge, and Mara Livezey

Majors Sandrine Zilikana ’12 and Mara Livezey ’13 and biology major Lindsey Gaston ’12  joined chemistry department faculty members Regina Stevens-Truss and Laura Lowe Furge at the American Society for Biochemistry and Molecular Biology Meeting in San Diego in late April. The students presented results of their summer research experiences (part of the Senior Individualized Projects for Sandrine and Lindsey) as part of both the Annual Undergraduate Poster Competition and the regular scientific sessions of the meeting.

More than 200 students from schools across the country were part of the undergraduate poster competition.  Zilikana’s research measured differences in reducing the potential of cancer cell types to affect drug delivery. She conducted this scientific work at the University of Michigan with Professor Kyung-Dall Lee.  Gaston’s showed that a specific hormone prevented nerve cell death after brain injury. Her research, conducted with Professor Vishal Bansal at the University of California-San Diego, will be included in a manuscript just accepted to the Journal of Neuropathology and Experimental Neurology. Livezey presented the results of a study she has worked on for the past two years in Furge’s lab modeling the interactions of inhibitors with human cytochrome P450 enzymes. That study was recently published in Drug Metabolism Letters. While in San Diego, Stevens-Truss directed a teaching workshop for middle school and high school science teachers in the San Diego area. Her innovation in development of the workshop has drawn increasing numbers of teachers to the workshop and provided a new platform for scientists to collaborate with and mentor the nation’s secondary school science teachers.

The workshop was funded by a grant from the National Science Foundation. Next year’s meeting will be in Boston, and Stevens-Truss and Furge plan to attend with another group of students. Stevens-Truss will also lead another teaching workshop there.

Biochemistry Beats Biceps

A beefcake pose doesn’t always a great male model make. Sometimes it takes a yeast two-hybrid trap for proteins. Two photos of Tanav Popli ’11 are featured on the video advertisement for the American Society for Biochemistry and Molecular Biology annual meeting (Tanav is pictured in slides 18 and 19, wearing a gray sweater with an argyle pattern).

The photos are from last year’s meeting in Washington, D.C., at which Tanav presented the results of his Senior Individualized Project work completed at University of California-San Francisco. His poster was titled: “Tmtc4 interacts with C3G, Wntless, and Zfhx4: a yeast two-hybrid trap for proteins associated with development of the corpus callosum.”

“I think he has returned to that USCF lab as a technician while he applies to medical school,” says Laura Furge, associate professor of chemistry. “There are three students that have just this week submitted abstracts to attend the 2012 meeting in San Diego,” she added.

They are: Mara Livezey ’13Sandrine Zilikana ’12, and Lindsey Gaston ’12. Travel for students to this meeting is provided by a grant to Kalamazoo College from the Howard Hughes Medical Foundation.

Five “K” Students Compete in Poster Presentation for ASBMB

Five Kalamazoo College students
Left to Right: Popli, Nagy, Diffenderfer, Parson, and McNamara

Kalamazoo College enjoyed a strong scientific presence at the Washington, D.C. meeting of the American Society for Biochemistry and Molecular Biology (ASBMB). Associate Professor of Chemistry Laura Furge served as a judge in the 15th Annual Undergraduate Poster Competition, in which five “K” students competed against more than 200 other undergraduates from throughout the country.

Laura Diffenderfer ’11 presented a poster titled “Autodock as a method for predicting binding for substrates and inhibitors of human cytochrome P450 2D6,” based on a sliver of the research she’s conducted for the past two years in Furge’s lab. Diffenderfer plans to attend Wayne State Medical School this fall. Alyssa McNamara ’11, a four-year denizen in the lab of chemistry professor Regina Stevens-Truss, presented “Suramin discriminates between the calmodulin-binding sites of neuronal and inducible nitric oxide synthase.” She will work for the Schuler Family Foundation in Chicago before she enrolls in medical school in 2012.

Leslie Nagy ’09 and Diffenderfer presented “Mechanism-based inhibition of human cytochrome P450 2D6 by Schering 66712,” work recently accepted for publication in Drug Metabolism and Disposition. Nagy is completing a two-year appointment as a laboratory research associate in Furge’s lab.

Tanav Popli ’11 presented a poster based on his SIP work at University of California-San Francisco. His poster was titled “Tmtc4 interacts with C3G, Wntless, and Zfhx4: a yeast two-hybrid trap for proteins associated with development of the corpus callosum.” Tanov plans to work in a laboratory after graduation and then apply for an M.D./Ph.D. program.

Emily Parson ’11 presented a poster titled “Characterization of a real time PCR assay for the detection and quantification of Plasmodium malariae parasites.” She did her SIP, which was based in part on her study abroad experience in Kenya, at the Walter Reed U.S. Army Medical Research Unit in Washington, D.C. After she graduates this spring, Emily will return to Walter Reed to continue research in related areas.

“Attendance at a national meeting is a tremendous opportunity for students to hear and meet leading scientists, to see how scientists share ideas with each other, and to see how scientific research accumulates and allows for the formation of new hypotheses,” said Furge.

And it’s an opportunity that depends on philanthropy. Student travel to this meeting was supported by a grant to “K” from the Howard Hughes Medical Institute. Popli received a travel award from the Undergraduate Affiliation Network of Kalamazoo College headed by Stevens-Truss. Stevens-Truss organized the first annual ASBMB workshop titled: “Fostering Partnerships Between Colleges/Universities and Junior High School Teachers,” and she noted that it got off the ground despite her absence due to and airline grounding. “I was disappointed to miss the workshop when my flight was grounded in Kalamazoo,” said Stevens-Truss. “But I’m glad the idea is now a successful reality.”

The second offering of the workshop will occur next April in San Diego.