chemistry

K at EB

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Victoria Osorio '16 and Sarah Glass '17
Victoria Osorio ’16 and Sarah Glass ’17

Two Kalamazoo College chemistry majors, Victoria Osorio ’16 and Sarah Glass ’17, attended the annual Experimental Biology meeting in San Diego, Calif. Experimental Biology is a joint meeting of six different societies including the American Society for Biochemistry and Molecular Biology (ASBMB) as well as societies for physiology, nutrition, pharmacology, pathology, and anatomy. “The meeting is a great opportunity for students to present their work and attend a variety of engaging scientific talks,” says Laura Furge, the Roger F. and Harriet G. Varney Professor of Chemistry. “There were more than 15,000 scientists in attendance.”

Osorio and Glass presented results of their research as part of the Undergraduate Poster Competition and as part of the regular scientific session for ASBMB. Their presentations centered on recent work in the Furge lab with protein variants of an important human liver enzyme called CYP2D6. CYP2D6 helps the human body process drugs. The titles of the Osorio and Glass posters were, respectively, “Susceptibility of Four Human CYP2D6 Variants and One Active Site Mutant to Inhibition by the Mechanism-based Inactivator SCH 66712” and “Activity and Kinetic Characterization of Human CYP2D6 Polymorphisms with Bufuralol and Dextromethorphan.”

There were more than 225 undergraduate posters in the ASBMB competition from students across the country and from a variety of college and universities. One Grand Prize and four Honorable Mention awards were presented to students in each of the four research topic categories (proteins and enzymes / metabolism, bioenergetics, lipids and signal transduction / DNA, chromosomes, and gene regulation / cellular and developmental biology). Glass won an Honorable Mention for the “Proteins and Enzymes” category and was recognized the next day in front of an audience of hundreds of scientists, educators and students at the award lecture for outstanding contributions to education. Glass’s presentation was based on the culmination of nearly three years of research in the Furge lab; Glass will complete her SIP with Furge this summer and the lab hopes to publish the results later in 2016 along with co-author Osorio and other recent Furge lab research assistants.

After graduation, Osorio will enter the Post-baccalaureate Research Education Program at Case Western Reserve University. Glass will complete her degree in Fall 2016 (two terms early), and she plans to start graduate school in biochemistry or pharmacology in 2017.

Travel to ASBMB for Osorio and Glass was supported by a grant to Furge from the National Institutes of Health. Glass also received an ASBMB Travel Award of $500.

Next year’s Experimental Biology meeting will be in nearby Chicago, Illinois, says Furge, “and we hope to take a large group of students from the Departments of Chemistry and Biology.”

Diamonds in the Rough

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Tom HigginsTom Higgins ’92 returned to his alma mater in early April as part of a visit coordinated by the Kalamazoo Section of the American Chemical Society. Higgins talked about “How Undergraduate Research Experiences Can Change Students’ Lives.” He should know.  Higgins and a number of collaborators have made great strides in cultivating future scientists by introducing undergraduate research experiences for students at two-year institutions. Known as STEM-ENGINES (Engaging the Next Generation in Exploring STEM), their research collaborative has enabled over 286 Chicago-area students, including many first-generation American citizens, to gain academic-year and summer research experience mentored by chemistry and biology faculty. Often these “diamonds in the rough” may not have envisioned research as a potential career path.

The K chemistry major cites his foreign study experience (Erlangen, Germany) as a source of insight and empathy into his own students’ discomfort in learning beyond their comfort zone. He sees community colleges as important part of the higher education landscape and his research demonstrates that small investments in a student can have a big payoff benefiting individuals, families, institutions, and communities.

Higgins is a program director in the National Science Foundation’s Division of Undergraduate Education, and he also serves as a professor at Harold Washington College, one of the City Colleges of Chicago.
He began teaching at Harold Washington in 1998 after completing his Ph.D. at Northwestern. He never thought he’d be there as long as he has been, but–as he told an audience of students and faculty from K, Western Michigan University and Kalamazoo Valley Community College– the atmosphere created by small class sizes made it hard to leave.

Text and photo by Ann Jenks

Research Reveals Enzyme’s Role in Shifting-Eyed Fish

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Rina Fujiwara '14 and Leslie Nagy '09
Rina Fujiwara ’14 and Leslie Nagy ’09 in the Vanderbilt University laboratory of Dr. Fred Guengerich. As Leslie was completing her rotation in the laboratory Rina was just beginning hers, so Leslie helped train Rina. Both scientists did important research on a key enzyme in fish and humans.

Sometimes science uncovers a pretty interesting “what” long before researchers learn that particular “what’s” equally interesting “how.”

Two Kalamazoo College alumnae are among the authors of a recently published paper describing HOW certain fish change their eyes to see more effectively in different water environments. Such a shift in visual acuity is a pretty cool “what” that’s been known for a while. Even some of the “how” had been elucidated–like knowing the components of a room’s light switch for example. What had been unknown–until now–was the enzyme responsible for the change, or, in other words, the finger that flips the switch.

The two co-authors who share K science ancestry, so to speak, are Rina Fujiwara ’15 and Leslie Nagy ’09. Both did the research described in the paper while working in the laboratory of Fred Guengerich at Vanderbilt University. Guengerich happens to have been the thesis advisor of Laura Furge, the Roger F. and Harriet G. Varney Professor of Chemistry at Kalamazoo College, when Laura was earning her Ph.D. at Vanderbilt. Both Nagy and Fujiwara worked in the Furge Lab during their undergraduate years; talk about scientific ancestry! The paper–titled “Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2”–appeared this week in the high impact scientific journal Current Biology. The Atlantic also published an article on the research.

It was in the Furge Lab that Nagy and Fujiwara were introduced to the cytochrome P-450 family of enzymes. They are critical mediators of many human physiological processes. “Today we know there are 57 P-450s in humans,” said Furge. “Many were known and their functions elucidated, but with the sequencing of the human genome, scientists discovered 13 unknown P-450s, which were dubbed ’orphans,’” she added. “Because the family is so important to human health, we’d like to know what these orphans do.” Fish and human share kindred P-450s, including the orphan, Cyp27c1, that’s the subject of the Current Biology paper.

For a full appreciation of the paper’s findings, a very simplified “Vision 101” may help. That we see–and how we see–depends in part on chemicals called chromophores. These share a common chemical backbone: vitamin A. Chromophores differ depending on modifications of their vitamin A, modifications that change an eye’s sensitivity to certain colors. For example, the vitamin A of sea fish–known as vitamin A1–help them better perceive a different spectrum of color than do freshwater fish, whose vitamin A2 allow for clearer vision in the red-wavelength light characteristic of rivers and lakes. Some fish–like salmon, that live in both marine and freshwater environments–can change their eyes by converting their vitamin A’s, from 1 to 2, sort of like gaining night vision goggles according the article in the Atlantic.

Just how they accomplish this conversion is the discovery that resulted from the research described in the paper. A single enzyme member of the cytochrome P450 family (one of the so called orphans, it turns out) converts A1 to A2, thus changing the color tuning of the fish eyes when the fish enters different water environments. And the human analog of that eye-changing P450 orphan in fish, the Cyp27c1 of the paper’s title–has also been studied by Guengerich Lab at Vanderbilt. A second paper on that analog is expected to be published in 2016, and Nagy and Fujiwara will co-authors of that paper as well.

Furge noted the impact and importance of scientific mentoring across generations, citing the example of Guengerich, herself, and Fujiwara and Nagy, representing three generations of cytochrome P-450 research. “Another K [and Furge Lab] alumna, Thanh Phanh ’15, is currently a technician in the Guengerich lab,” said Furge. “She hasn’t contributed to eye project but I’m sure she’ll have her own project in the future.”

Professor of Chemistry Jeff Bartz is the new Kurt D. Kaufman Chair at Kalamazoo College

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Professor of Chemistry and Kurt D. Kaufman Chair Jeff Bartz with some of his students in K's Dow Science Center
Professor of Chemistry and Kurt D. Kaufman Chair Jeff Bartz with some of his students in K’s Dow Science Center…

Professor of Chemistry Jeffrey Bartz, Ph.D., is Kalamazoo College’s new Kurt D. Kaufman Chair. His appointment—made at the recommendation of Provost Mickey McDonald and confirmed by the College’s board of trustees—becomes effective July 1, 2015, and runs through June 30, 2020.

The chair was established through a gift by late Kalamazoo College Trustee Paul Todd ’42 in recognition of Kurt Kaufman’s significant leadership and wide influence as a faculty member at K. It’s awarded to a K faculty member to “recognize and honor campus leadership and excellence in teaching.” Regina Stevens-Truss (Chemistry) has held the Kaufman Chair for the past five years.

“I offer my warmest congratulations to Professor Bartz,” said K President Eileen Wilson-Oyelaran. “Provost McDonald’s recommendation highlights Professor Bartz’s ongoing excellence as a teacher in the classroom, in the laboratory, and as a mentor. He is known as a teaching innovator on campus and for mentoring and supporting students of color and first-generation students.”

Professor Jeff Bartz with three students at K's laser lab
…and in the College’s Laser Lab.

Jeff Bartz joined the K chemistry department as an assistant professor in 1997 and became a full professor in 2011. He teaches courses in physical and general chemistry and works with K students in the research laboratory. His research is in the area of chemical dynamics.

He earned a B.S. degree in chemistry with a minor in mathematics from Southwest Minnesota State University in 1985 and his Ph.D. degree in physical chemistry at the University of Wisconsin-Madison in 1992.

Visit Professor Bartz’s webpage.

Kurt Kaufman was a professor of chemistry at K from 1956 to 1980 who was lauded by students and faculty colleagues as an accomplished researcher and gifted communicator who loved to teach. He died in 2008.

K’s 3 of 300

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Rina Fujiwara
Rina Fujiwara

Three Kalamazoo College chemistry majors presented at the 2015 Experimental Biology meeting, a joint meeting of six different societies including the American Association for Biochemistry and Molecular Biology (ASBMB) as well as societies for physiology, nutrition, pharmacology, pathology, and anatomy. More than 15,000 scientists attended the meeting in Boston, Massachusetts.

Rina Fujiwara ’15, Sarah Glass ’17, and Victoria Osorio ’16 shared results of the research they did in collaboration with Professor of Chemistry Laura Furge. Their presentations were part of both the Undergraduate Poster Competition and as part of the regular scientific session for ASBMB. Some 300 undergraduate posters composed the ASBMB competition from students across the country and from a variety of college and universities.

Fujiwara’s work, part of her Senior Individualized Project (SIP), showed how the work of two human liver enzymes vital to the body’s processing of medicines is halted by two small molecule inhibitors. The research took place in the Furge lab at Kalamazoo College and was published in Drug Metabolism and Disposition (Fall 2014). Other co-authors included Furge, Amanda Bolles ’14, and Erran Briggs ’14.

Victoria Osorio
Victoria Osorio

Glass and Osorio presented a poster that centered on recent work in the Furge lab with variants of an enzyme responsible for metabolism (or processing in the body) of about 15 percent of all medicines. The presence of these enzyme variants in different individuals can lead to vastly different responses to some pharmaceutical drugs, including cough syrup, the breast cancer drug tamoxifen, and many more. Though not present at the meeting, Mike Glista ’06) and Parker de Waal ’13) were co-authors on the posters.

This summer Fujiwara will enter the University of Pennsylvania Graduate Program in Biochemistry and Molecular Biophysics. Osorio and Glass will continue research with Furge this summer. Both plan to attend graduate school after graduating from Kalamazoo College.

Sarah Glass
Sarah Glass

At the Boston meeting Professor of Chemistry Regina Stevens-Truss once again directed her highly acclaimed HOPES project, connecting science teachers with practicing scientists to enhance the quality and hands-on authenticity of primary and secondary classroom science instruction.

Professors Furge and Stevens-Truss are members of the ASBMB and attend the meeting every year. Travel to ASBMB for students Fujiwara, Glass, and Osorio was supported by grants from the Richard J. Cook Research Fellowship Fund (Fujiwara), an award from the ASBMB Student Affiliate (Fujiwara), the Provost Office (Glass, Osorio), and a grant to Furge through the National Institutes of Health (NIH). Travel for Furge and Truss was supported by the Hutchcroft Endowment as well as NIH and grants from ASBMB.

Chemistry Explosion at Kalamazoo College

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Three chemistry students wearing goggles in the laser lab at KSome chemical reactions are simply impressive—the vibrant flash of light when magnesium is ignited or the blast and subsequent grains of salt that appear after mixing sodium metal and chlorine gas.

Equally impressive is the reaction to the chemistry major at Kalamazoo College in recent years.

Sixty-eight students—41 males and 27 females—declared chemistry as their major at Declaration of Major Day. The annual event, held the fifth week of winter quarter, requires sophomores to declare their majors, minors, and concentrations.

“Fifteen percent of the sophomore class [the class of 2017] chose chemistry,” says Laura Lowe Furge, the Roger F. and Harriet G. Varney Professor of Chemistry and current chair of the department. “On a per capita basis, it probably makes K the largest chemistry program in the country.”

To accommodate the growth of chemistry majors, a new faculty member will join the department this fall, and additional classes and lab times have been added to the schedule, Furge explains.

“It’s a good problem for us to have,” she says.

Space, she admits, is an issue as labs and lecture halls in the 23-year-old Dow Science Center were built to house a much smaller student population. In 1998, for example, only six students at K graduated with a chemistry degree.

“We’ve had to make some allowances,” she says. “The hope is to eventually expand the building to provide additional lab space, classrooms, and faculty offices.”

While the number of recently declared majors is impressive, it is part of a growing trend. The class of 2016 includes 55 chemistry majors and this year’s senior class will graduate 30 students with degrees in chemistry.

According to Greg Slough, professor of chemistry, the faculty has worked to change the perception of difficulty associated with a chemistry major.

“We’re making chemistry doable for students,” Slough explains. “There is a real student focus among every faculty member. The students know that we’re here for them, we’re approachable, and we’re here to help when the work gets tough.”

Professor of Chemistry Jeffrey Bartz adds that the department’s deep commitment to evidence-based education has helped it evolve.

“Every class changes, every single year,” Bartz explains. “We’re not teaching students the same thing, the same way, year after year.”

One of those students is Bryan Lara, a sophomore from California, who selected chemistry on Declaration of Major Day.

“Every chemistry professor knows my name,” Lara says. “I’m not just a number. There is a real sense of community among the faculty and students.”

He adds that extracurricular chemistry activities such as the Dow Open, a miniature golf event held inside the Dow Science Center, the October 23 Mole Day celebration, and the annual Dow-B-Q help keep students engaged and excited about the major.

And if recent years are any indication, this excitement won’t be waning anytime soon. (Text by Erin Dominianni ’95)

Challenge and Imagination: Working Science at K

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Kalamazoo College alumnus Parker de Waal
Parker de Waal ’13

Parker de Waal ’13 had a wish: he wanted to work on a computational chemistry project.

Laura Furge, the Roger F. and Harriet G. Varney Professor of Chemistry, had a challenge: she needed models of the variants of an important human enzyme. (Some background: The aforementioned enzyme, found in the liver, helps the body process medicines, but it’s not exactly the same–hence, variants–in all individuals. Such variability means some people react differently (including adversely) to important medicines. That’s a serious health problem, and part of Furge’s current grant from the National Institutes of Health calls for the study of these variants. And for such study a model of the variants’ structures would certainly be useful!)

In spring 2013, wish met challenge, and, one year later, the two researchers (along with co-author Kyle Sunden ’16) have published a paper in PLoS ONE, the online journal of the Public Library of Science.

That culminating publication traces back to a laboratory question: Could de Waal (a student in Furge’s “Advanced Biochemistry” class) make computational models of the variants? “I suggested some different ways to approach the problem,” says Furge, “and those approaches took Parker all of about two days!” It was at that point that de Waal suggested to Furge some different, more powerful computational approaches–specifically, molecular dynamics using more sophisticated software. “I said, ’Let’s go for it!’” says Furge. “And we both started on the journey to learn more about Molecular Dynamics approaches.”

The journey included consulting with other scientists around the country and the world (Germany, the Czech Republic) both by email and in person at various scientific conferences. Furge and de Waal used a supercomputer at the University of Texas for the computational work. Analysis of the resulting structures was completed by Furge and Sunden during the winter and spring terms of 2014. “The project is a beautiful example of how research and teaching go together at K,” says Furge. The work has been presented at two major medical meetings.

The paper includes 21 figures and tables. Parker de Waal performed all the experiments that led to the figures; Sunden did the experiments and analyses for two of the figures. Furge did the majority of the analysis. In true liberal arts fashion, the cross-disciplinary work combines computer science and biochemistry. Furge taught Sunden, a chemistry and computer science double major, the relevant biochemistry as they progressed with the project. Sunden hopes to continue the work for his Senior Individualized Project after he returns from study abroad in Australia. The work may one day contribute to personalized solutions for people who have adverse drug reactions to important medicines. The paper has had more than 300 views in the six weeks since it’s been published.

Great academics, cross-disciplinary collaboration, research at the edge, and science that matters! Science education at Kalamazoo College: a double helix of challenge and imagination.

K Professor and Students Publish Important Chemistry Research

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K students Rina Fujiwara, Erran Briggs and Amanda Bolles with Professor Laura Furge
Medicinal researchers and members of the Furge Lab (l-r): Rina Fujiwara, Erran Briggs, Amanda Bolles, and Laura Furge

Laura Furge, the Roger F. and Harriet G. Varney Professor of Chemistry at Kalamazoo College, is the senior and corresponding author of an important scientific paper that includes three Kalamazoo College student co-authors: Amanda Bolles ’14, Rina Fujiwara ’15, and Erran Briggs ’14. The paper is titled “Mechanism-based Inactivation of Human Cytochrome P450 3A4 by Two Piperazine-containing Compounds” and appears in Drug Metabolism and Disposition, a highly regarded, high impact international journal published by the American Society for Pharmacology and Experimental Therapeutics. The research the paper describes, which was conducted in the Furge Lab on K’s campus, contributes the understanding of how some drugs “apply the brakes to” the activity of an enzyme–in this particular case, an enzyme important to the metabolism (or processing) of about half of all medicines! What are the human implications of the work? “Many individuals take multiple medicines each day,” said Furge. “Multiple-drug regimens can lead to unwanted side effects, including drug-induced inhibition of the very enzymes responsible for the metabolism and clearance of other co-administered drugs.” In fact, side effects from drug interactions of polypharmacy therapy are the number one cause of hospitalization in the U.S. “This paper adds in understanding of how certain classes of drugs may cause this type of unfavorable medical event,” said Furge. “New insights will hopefully lead to better prevention in the future.”

The paper includes 13 figures and tables. Furge noted that Bolles, Fujiwara, and Briggs performed all the experiments that lead to those figures, and “all the work was done on the campus at Kalamazoo College. We had all the equipment here needed to complete these studies, and we have already started full swing on another set of experiments for a future publication.” The students have presented parts of the preliminary data at national meetings in the past year, and the research forms of basis of the Senior Individualized Projects for Bolles and Fujiwara.

Such research, and the extraordinary educational opportunities it provides for K students, requires the cooperation, coordination, and collaboration of many funding sources. “This is so important,” Furge stressed. The Richard Cook Fellowship and the Alan and Elaine Hutchcroft Fund (endowments created and supported by alumni gifts) paid for the summer stipends of Fujiwara and Bolles, respectively. The mass spectrometer essential to the experiments was paid for in part by the Hutchcroft Fund and a grant from the Howard Hughes Medical Institute. The research also was funded by grants Furge secured from the National Institutes of Health.

“Drug Metabolism and Disposition is an international journal with a high impact factor,” added Furge. Impact factors measure how frequently manuscripts in a journal are referenced by other authors.

Small School; Big Experiments

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Professor of Chemistry Jeff Bartz in the laser labThis past spring Professor of Chemistry Jeff Bartz (pictured at left with two students in his laser laboratory) received word that the National Science Foundation would provide a three-year grant to Kalamazoo College so that Bartz’ lab could conduct new experiments to evaluate how the shape of a molecule influences the mechanics of its dissociation into smaller fragments. The work began this summer and involved four students: Mara Birndorf ’16, Jeremy Lantis ’16, Braeden Rodriguez ’16, and Marlon Gonzalez ’17. And there’s nothing quite as effective as complementing classroom work with hands-on real-world experience. “My chemistry classes taught me the fundamentals, but the research is giving me an idea of what a physical chemist does,” said Birndorf. Bartz agrees: one of the great benefits of the NSF grant is its effect on students, who “move from seeing themselves as students to seeing themselves as scientists.” On a typical weekday morning these young chemists are using lasers in the type of experiments that Bartz long ago thought were unlikely to ever be performed here. After all, smaller schools do face the challenges of getting their research swallowed up by larger institutions with more resources (not to mention graduate students) to conduct a project. Despite those challenges, Bartz finds an angle for K to contribute to new scientific work. “We have to evolve if we want to continue to work at the forefront.” Like most new science, what’s going on in Bartz’ lab derives from previous work. Niclas West ’12 presented a talk, “Velocity-mapped ion imaging of methyl nitrite photodissociation,” in 2010 at the 65th International Symposium on Molecular Spectroscopy. Researchers from Texas A&M found the abstract online and approached the K team about the similarities between the two teams’ experimental techniques. The two groups decided to collaborate on the publication of a paper, “A method for the determination of speed-dependent semi-classical vector correlations from sliced image anisotropies,” which included K student co-authors West and Kelly Usakoski ’14. After this paper came out in The Journal of Chemical Physics, Bartz began work on the proposal the NSF funded last spring. “We are looking at information gaps in previous work that our current experimental techniques can help fill,” Bartz said, “sort of testing old experiments in new ways. It’s kind of a K niche we’ve carved out.” (text by Colin Smith ’15)

Four in More Than 15,000

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Three female students who presented at the 2014 Experimental Biology Meeting
K student researcher/presenters at the 2014 Experimental Biology Meeting included (l-r): Amanda Bolles, Rina Fujiwara, and Virginia Greenberger. Not pictured is Michael Korn.

Four Kalamazoo College students attended at the 2014 Experimental Biology Meeting: Amanda Bolles ’14, Chemistry; Rina Fujiwara ’15, Chemistry; Virginia Greenberger ’14, Chemistry; and Michael Korn ’14, Biology. Experimental Biology is a joint meeting of six different societies including the American Association for Biochemistry and Molecular Biology (ASBMB) as well as societies for physiology, nutrition, pharmacology, pathology, and anatomy. The meeting provides a great opportunity for students to present their work and attend a variety of engaging scientific talks. More than 15,000 scientists attended the event in San Diego, Calif.

Bolles and Fujiwara presented their research findings during the Undergraduate Poster Competition and during the regular scientific session for ASBMB. Their research involves recent work completed in the laboratory of Professor of Chemistry Laura Furge. That work has shown that two different (but related) compounds inactivate P450 3A4, an enzyme in the liver and intestine that metabolizes (or processes) a major pharmaceutical drug. The titles of the Bolles and Fujiwara posters were, respectively, “5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1 piperazinyl]pyrimidine is a mechanism based inactivator of CYP3A4” and “Mechanism-based inactivation of human CYP3A4 by a piperazine-containing compound.” The ASBMB competition includes posters of some 300 students from a variety of college and universities across the country. One grand prize award was presented to a student in each of four research categories (bioenergetics/protein structure, cell biology/developmental biology, DNA/gene regulation, and immunology/microbiology/neurobiology). Bolles won the $500 grand prize in the bioenergetics/protein structure category and was recognized the next day before an audience of hundreds of scientists, educators, and students at the award lecture for outstanding contributions to education. Bolles’s presentation derived from her Senior Individualized Project (SIP), which will be published later this year along with results from co-author Fujiwara.

Greenberger conducted her SIP research in the laboratory of Professor of Chemistry Regina Stevens-Truss. The abstract she presented at the meeting was titled “Bacterial Action of Novel Cationic Peptide Sequences.” As more antibiotic resistance is observed in patients, new sources of antibiotics are being investigated, including short peptide sequences. Greenberger’s work in the Truss lab was aimed at determining the antibiotic activity (and the precise mechanisms of action that yielded the activity) of two newly studied peptide sequences.

Dr. Furge also presented a poster in the ASBMB regular scientific session based on work started last year by Parker de Waal ’13. The work began as part of a course assignment in Furge’s “Advanced Biochemistry” course and grew into an elegant computational study of structural differences between select variants of the drug-metabolizing enzyme P450 2D6. de Waal used molecular dynamics methods to show how subtle differences in the enzyme structure can help explain differences in the metabolizing abilities of the enzymes. The study is being completed by Kyle Sunden ’16. While in San Diego, Furge spent an afternoon at the Skaggs School of Pharmacy at the University of California-San Diego discussing the implications and approach of the study with other scientists in this field.

Korn attended the American Physiological Society (APS) portion of the Experimental Biology meeting. He presented the results of his SIP work (conducted in the laboratory of Dr. Christopher Mendias at the University of Michigan) in the APS Student Poster Competition. Korn’s abstract received the David Bruce Outstanding Undergraduate Abstract Award. The title of his presentation was “Simvastatin reduces myosteatosis following chronic skeletal muscle injury.”

The future is promising for all four of these outstanding student researchers. In the fall, Bolles will enter the University of Michigan Graduate Program in Biomedical Sciences; Greenberger will matriculate to the chemistry department at Pennsylvania State University to begin work on her Ph.D; Korn will attend the University of Michigan Medical School; and Fujiwara will complete her SIP with Furge this summer. She plans to attend graduate school after her June 2015 graduation from K.

Professors Furge and Truss are both members of the ASBMB and attend the annual meeting each year. Truss also directs a National Science Foundation (NSF)-funded workshop for area high school science teachers in connection with the annual ASBMB meeting. This year’s workshop attracted more than a dozen local teachers who learned science and teaching strategies to use in their classrooms. Attendees at the workshop are also eligible for mini-grants to support further development of their teaching after the workshop. A recent article describes the impact of this workshop (which is in its fourth year).

In other meeting news, the Ruth Kirschstein Diversity in Science Award was given jointly to President Freeman Hrabowski III and Professor Michael Summers of University of Maryland-Baltimore County. Professor Summers was the SIP mentor to Erran Briggs ’14 and has worked closely with Professor Truss on the Professional Development and Minority Affairs Committees of ASBMB. Professor Summers also visited K’s campus in 2010 as a Howard Hughes Medical Institute Guest Scholar Lecturer. Given the connections, and important work of Summers and Hrabowski, Professor Truss arranged for Bolles, Fujiwara, and Greenberger to interview Summers for Kalamazoo College’s Arcus Center for Social Justice Leadership’s Praxis Center. Following the interview, Summers treated the students and Truss to lunch overlooking the San Diego Harbor marina! Notes from the interview will be posted on the Praxis website.

Travel to ASBMB for Bolles, Fujiwara, and Greenberger was supported by grants from the Provost Office, the Heyl Foundation (Greenberger), and the ACSJL. Korn’s travel to the meeting was sponsored by grant funds from his SIP advisor and the University of Michigan. Furge and Truss were supported by the Hutchcroft Endowment as well as their NIH and NSF grants, respectively. Next year’s Experimental Biology Meeting will occur in Boston, Mass.