chemistry

Good Chemistry

Posted on
Lori-Ann Williams, Geneci Marroquin and Josh Abbott wearing goggles in a lab
Lori-Ann Williams, Geneci Marroquin and Josh Abbott in the lab.

It’s summertime at K; the weather is hot, and so is the chemistry on the second floor of the Dow Science Center. In the first of a series of articles, we focus on chemistry research underway on campus during summer 2013.

Three students are advancing ongoing research projects in the inorganic chemistry laboratory of Professor of Chemistry Tom Smith. Each project is focused on elements included in a group known as transitional metals. Josh Abbott ’13, Lori-Ann Williams ’14, and Geneci Marroquin ’14 apply various techniques to characterize reactions that occur in nature (as well as some chemistry that nature doesn’t do) involving the elements vanadium (Abbott), manganese (Williams), and cobalt and nickel (Marroquin).

The researchers are working to create small molecule models that are motivated by the chemical reactions that occur in nature and involve more complex substances such as enzymes. All three are performing the intricate chemical experiments required to make crystal samples of molecules that result from the aforementioned reactions—enough samples, and of sufficient quality, for the technique known as x-ray crystallography, which will render a three-dimensional portrait of the molecule.  (The notion of portraiture is particularly apt for the chemistry of transitional metals, known for their colors and alterations of color as a result of molecular changes.) The x-ray crystallography work will mean an August trip to Purdue University (the workplace of a long-time collaborator with Smith in these scientific projects) for Smith and the student researchers.

The work of Williams and Marroquin will form the basis of their respective Senior Individualized Projects. Williams’ work, says Smith, is more biologically oriented, and seeks to reconcile data on manganese compounds from Williams and the Smith lab with data published on manganese work from a laboratory in India. Marroquin’s is more “catalytically oriented, doing something nature doesn’t do,” she says. If Marroquin’s contribution to the ongoing project is successful, subsequent work may one day lead to more efficient energy generation. “We’re trying to save the world in this lab,” smiles Marroquin.

Abbott graduated in June but wanted to more research work in inorganic chemistry, the most liberal arts-ish of all chemistry disciplines. “It relates to all other branches of chemistry and science and is very useful for better understanding of peer-reviewed literature in biochemistry,” he said. His vanadium research originates from the way sea algae synthesize special organic molecules for self protection.

It’s been a good summer in Smith’s lab. All five of his researchers are “highly motivated and getting a lot done,” Smith said. (Leland O’Connor ’14 and Mojtaba Ahkavandafi ’15 were not in the lab the day we dropped in, and they are working on projects very different from those of the other students.)

Strong K Presence at National Science Meeting

Posted on
Six students presented research work at the annual ASBMB meeting
Six students presented research work at the annual ASBMB meeting. From left: Josh Abbott, Erran Briggs, Amanda Bolles, Mara Livezey, Michael Hicks, and Nic Sweda. Hicks is a biology major; the other five are majoring in chemistry.

Six Kalamazoo College students joined two of their chemistry professors and mentors (Regina Stevens-Truss and Laura Lowe Furge) at the American Society for Biochemistry and Molecular Biology National Meeting in Boston, Mass. The students–Nicholas Sweda ’13, Mara Livezey ’13, Michael Hicks ’13, Josh Abbott ’13, Amanda Bolles ’14, and Erran Briggs ’14–presented results of their summer and academic year research experiences (Senior Individualized Projects in the cases of Nick and Josh). Nearly 300 posters from colleges across the country were part of the 17th Annual Undergraduate Student Research Poster Competition and Professional Development Workshop. Professor Furge was a judge in the competition.

The lab of Professor Paul Hollenberg at the University of Michigan was the site of Abbott’s SIP research on the role of CYP2B6 metabolism of the chemotherapeutic drug cyclophosphamide. The other five posters were based on research done at Kalamazoo College. Sweda presented ongoing studies from Professor Stevens-Truss’s lab on suramin selective inhibition of nitric oxide synthases. This work is the basis of a manuscript in preparation with Sweda and Alyssa McNamara ’11 as co-authors. Livezey, Hicks, Bolles, and Briggs each presented individual posters with results of three projects from Professor Furge’s lab on the interactions of inhibitors with human cytochrome P450 enzymes. The work presented by Bolles and Briggs is currently being prepared in a manuscript for publication with both students as co-authors along with Livezey. The posters presented by Hicks and Livezey are the basis of current NIH-funded studies in the Furge lab. In addition to the poster sessions, students attended talks, award lectures, and exhibits. Students also met with graduate school recruiters.

During the meeting, Professor Stevens-Truss directed her third annual teaching workshop for middle school and high school science teachers in the Boston area. The workshop attracted more than 70 teacher-participants from the Boston area, a record number for these ASBMB associated events. Professor Stevens-Truss’s efforts in structuring the workshops have provided a new platform for scientists to collaborate and mentor the nation’s secondary school science teachers. Scientists from across the country helped make the workshop a meaningful experience for school teachers. It was funded by a National Science Foundation grant to Stevens-Truss. Next year’s meeting will be in San Diego, Calif., and K expects to be there.

Kalamazoo Senior Ashleigh Holden Earns a STAR

Posted on

 

Ashleigh Holden with a horse
K senior Ashleigh Holden (Photo by Matt Gade, MLive / Kalamazoo Gazette)

When K senior Ashleigh Holden isn′t studying chemistry or guiding prospective students around the campus for the K Admissions Office, she′s often at the Cheff Therapeutic Riding Center in Augusta, east of Kalamazoo. During the last year alone, Ashleigh has amassed more than 475 hours helping to deliver hippotherapy, a physical, occupational, and speech-language therapy that utilizes horses to provide aid to clients with a variety of special needs. For her efforts, Ashleigh has earned the 2013 College Volunteer STAR (Sharing Time and Resources) Award, a partnership between Volunteer Kalamazoo and MLive/Kalamazoo Gazette to honor outstanding volunteers in Southwest Michigan. Congrats, Ashleigh. You truly are one of K′s stars.

K’s Chem Club Sieves Out Victorious

Posted on
Lydia Manager, Mara Livezey, Joe Widmer, Amanda Bolles, Josh Abbott and Tibin John
2013 Winners of the Battle of the Chemistry Clubs are (l-r): Lydia Manager ’13, Mara Livezey ’13, Joe Widmer ’14, Amanda Bolles ’14, Josh Abbott ’13, and Tibin John ’15

Kalamazoo College’s American Chemical Society (ACS) student group brought home to the chemistry department the coveted ‘Silver Sep Funnel’ Trophy from Michigan State University this winter. The students pipette-ed, read spectra, analyzed, and even danced their way to victory, and as the safest team (“which is the most important part for us,” says Regina Stevens-Truss, who shares co-advising duties for the group with fellow chemistry professor Jeff Bartz). The K ACS student group participated last year for the first time and placed sixth. This year, they won the overall competition, brought home best “safety dance,” earned most artistic accolades for the “best scientific-themed hangman,” and were also the “safest working team” based on OSHA standards.

2013 was the sixth annual Battle of the Chemistry Clubs, an event that originally put into the pipette pit (so to speak) the University of Michigan-Flint against the University of Detroit Mercy. The field has since grown to 12 schools, with Kalamazoo College joining in 2012. Competition consists of several activities that test a team’s knowledge and skill as it pertains to different chemistry concepts. All activities are team based (each with 4 or more students) and are scored and ranked based on time or accuracy. Morning prelims are followed by the afternoon’s “playoffs mode,” with only one team taking home the hardware.

Josh Abbott was the only returning K “letter winner” from last year’s sixth-place team. He vowed then that K would be well represented this year and wrote immediately after this winter’s competition to Dr. Truss: “I would just like to let you know we brought some hardware back for Dow.” Sweet!

K Students Will Benefit from Chemistry Grant Renewal

Posted on

Professor of Chemistry Laura Furge has received a renewal of her National Institutes of Health (NIH) grant to support continued research in the area of drug-drug interactions. She will conduct this research with undergraduate science students at Kalamazoo College. Adverse drug-drug interactions are common among individuals who take multiple drugs (both over the counter and prescribed), particularly among older persons and among individuals whose bodies express variants of drug metabolizing (drug processing) enzymes. The research in the Furge lab will benefit human health by adding to the understanding of how certain classes of drugs may interact in individuals and cause drug-drug induced unfavorable medical events. Furge currently has five research students working in her lab and has mentored two dozen in her lab and many more in her classes over the past 13 years at K. Funding from the NIH will help ensure continued research opportunities for future generations of scientists. The grant will provide $225,000 over three years.

 

K Science Majors Present at Undergraduate Research Conference

Posted on
Six students who presented at the West Michigan Regional Undergraduate Science Research Conference
Scientific presenters at the West Michigan Regional Undergraduate Science Research Conference included (l-r): Carline Dugue, Josh Abbott, Amanda Bolles, Mara Livezey, Kelly Bresnahan, and Chelsea Wallace. Not pictured are Erran Briggs, Michael Hicks, Nicolas Sweda, and Associate Professors of Chemistry Laura Lowe Furge and Regina Stevens-Truss.

Nine Kalamazoo College science majors and two chemistry department faculty members (Regina Stevens-Truss and Laura Lowe Furge) attended the recent West Michigan Regional Undergraduate Science Research Conference in Grand Rapids. The students were Carline Dugue ’12, Chelsea Wallace ’13, Nicholas Sweda ’12, Mara Livezey ’13, Michael Hicks ’12, Kelly Bresnahan ’12, Josh Abbott ’12, Amanda Bolles ’14, and Erran Briggs ’14. Hicks and Wallace are biology majors; the others are majoring in chemistry. They presented results of their summer and academic year research experiences, including Senior Individualized Project work for Dugue, Bresnahan, Sweda, and Abbott. More than 170 posters from colleges across West Michigan were part of the conference’s poster session, and some 400 people participated in the conference. Dugue’s research focused on semiconductor quantum dots and charge transfer; she worked with Western Michigan University professor Sherine Obare. Abbott’s work focused on the role of a specific liver enzyme (CYP2B6) in the way the body processes the cancer drug cyclophosphamide. He did this work in the lab of Professor Paul Hollenberg at the University of Michigan. Bresnahan completed her SIP at the University of Michigan laboratory of Professor James Woods. She worked on animal models for testing of molecules called cholinergic receptor agonists for aid in smoking cessation studies. The other six posters described research done at Kalamazoo College. Sweda presented ongoing studies from Professor Stevens-Truss’s lab on suramin selective inhibition of nitric oxide synthases, part of a chain of events that affects production of nitric oxide in the human body. An excess of nitric oxide is associated with conditions such as Parkinson’s disease and Alzheimer’s disease. This work is the basis of a manuscript in preparation with Sweda and Alyssa McNamara ’11 as co-authors. Wallace’s research (with Associate Professor of Biology Blaine Moore) showed that BCL-2 is able to rescue neuroblastoma cells from ethanol toxicity. Livezey, Hicks, Bolles, and Briggs each presented individual posters with results of three projects from Professor Furge’s lab on the interactions of inhibitors with human cytochrome P450 enzymes. These enzymes metabolize compounds, including medicines, in the liver, and the inhibition of those enzymes may influence the effectiveness of current and new medicines. The work presented by Bolles and Briggs is currently being prepared in a manuscript for publication with both students as co-authors along with Livezey. The posters presented by Hicks and Livezey are the basis of a current NIH grant renewal to support ongoing opportunities for student research in the Furge lab. In addition to the poster sessions, students attended several lectures and were able to meet with graduate school recruiters.

K Connection Spans 30 Years in Internship

Posted on

Cassandra Fraser and Michael Paule-CarresCassandra Fraser, Class of 1984, is a chemistry professor at the University of Virginia. This summer she hosted Michael Paule-Carres, Class of 2014, in her laboratory, where he did research for his Senior Individualized Project. “It was kind of scary to contemplate that 30 year gap!” wrote Fraser, who had a good antidote for any mild “gap fear.” The formula included the excellence of the lab work Paule-Carres conducted. “He synthesized and characterized a luminescent polymer that will be used to make oxygen nanosensors for wound diagnostics, tumor hypoxia imaging, and other medical uses,” Fraser explained. And for extra measure, a few funny photos were added. “We took some research group pictures, including some of Mike (right) and me together, the Kalamazoo College chemists. We even attempted to make K’s with our bodies, not so successfully mind you, but maybe it’s the thought that counts.” Mike has returned to campus for the beginning of men’s varsity soccer practice.

 

Interference Implications

Posted on
Kalamazoo College student at a conference in San Diego
Mara Livezey discussing the work with other scientists in San Diego.

The peer-reviewed publication Drug Metabolism Letters has accepted for publication the manuscript “Molecular Analysis and Modeling of Inactivation of Human CYP2D6 by Four Mechanism Based Inactivators.”

In addition to Associate Professor of Chemistry Laura Furge, the senior and corresponding author, the manuscript has six student co-authors: Mara Livezey ’13, Leslie Nagy ’09, Laura Diffenderfer ’11,Evan Arthur ’09, David Hsi ’10, and Jeffery Holton ’13.

Their work described in this paper contributes to the understanding of how some drugs can halt the activity of an enzyme. In this case, the enzyme studied is one that is important for the body’s processing of about 20 percent of medicines, particularly treatments for arrhythmia and other heart diseases, depression, and other maladies. Such understanding is vital because many people’s health depends on daily regimens of multiple medicines. Sometimes one drug can interfere with the very enzymes responsible for the processing and clearance of other co-administered drugs. This and other unwanted side effects are the number one cause of hospitalization in America.

The paper’s contribution to the understanding of how certain classes of drugs cause this interference with key enzymes will hopefully lead to more effective prevention of the phenomenon in the future.

The K research was funded by grants from the National Institutes of Health and the Howard Hughes Medical Institute and by the Department of Chemistry Hutchcroft Fund. The latter was established by a gift from alumni Alan ’63 and Elaine (Goff) Hutchcroft ’63.

The final version of the study was presented at the San Diego meeting of the American Society for Biochemistry and Molecular Biology.

Science Grant Benefits Breast Cancer Research

Posted on
Professor Furchak at Dow with four chemistry majors
Professor Furchak in the Dow Science Building with Kalamazoo chemistry majors (l-r) Vinay Sharma ’12, Lydia Manger ’13, Eric Glanz ’13, and Amy Ong ’11

Herbert H. and Grace A. Dow Assistant Professor of Chemistry Jennifer R. Furchak has received a 2011 Cottrell College Science Award from the Research Corporation for Science Advancement. She will use the $35,000 award to further her work into the development of a multiplexed assay for the analysis of breast cancer metastasis.

“The potential impact of this work in detection and understanding of breast cancer metastasis lies in improvements in simplicity, accuracy, and speed over current methods, which could allow for improved patient treatment and prognoses,” she said. “Ultimately, additional sample throughput will result in better understanding of disease progression.”

According to Furchak, five student researchers at “K” have worked on this project thus far. It’s been the foundation for three completed Senior Independent Projects, and another is in progress this summer. Furchak’s grant is one of 48 Cottrell grants this year totaling $1.8 million and intended to support early career scientists at liberal arts colleges and primarily undergraduate universities.

Undergraduate students must be involved in the research in meaningful ways. Founded in 1912, Research Corporation for Science Advancement is the second-oldest foundation in the United States and the oldest foundation for science advancement.