K senior Ashleigh Holden (Photo by Matt Gade, MLive / Kalamazoo Gazette)
When K senior Ashleigh Holden isn′t studying chemistry or guiding prospective students around the campus for the K Admissions Office, she′s often at the Cheff Therapeutic Riding Center in Augusta, east of Kalamazoo. During the last year alone, Ashleigh has amassed more than 475 hours helping to deliver hippotherapy, a physical, occupational, and speech-language therapy that utilizes horses to provide aid to clients with a variety of special needs. For her efforts, Ashleigh has earned the 2013 College Volunteer STAR (Sharing Time and Resources) Award, a partnership between Volunteer Kalamazoo and MLive/Kalamazoo Gazette to honor outstanding volunteers in Southwest Michigan. Congrats, Ashleigh. You truly are one of K′s stars.
2013 Winners of the Battle of the Chemistry Clubs are (l-r): Lydia Manager ’13, Mara Livezey ’13, Joe Widmer ’14, Amanda Bolles ’14, Josh Abbott ’13, and Tibin John ’15
Kalamazoo College’s American Chemical Society (ACS) student group brought home to the chemistry department the coveted ‘Silver Sep Funnel’ Trophy from Michigan State University this winter. The students pipette-ed, read spectra, analyzed, and even danced their way to victory, and as the safest team (“which is the most important part for us,” says Regina Stevens-Truss, who shares co-advising duties for the group with fellow chemistry professor Jeff Bartz). The K ACS student group participated last year for the first time and placed sixth. This year, they won the overall competition, brought home best “safety dance,” earned most artistic accolades for the “best scientific-themed hangman,” and were also the “safest working team” based on OSHA standards.
2013 was the sixth annual Battle of the Chemistry Clubs, an event that originally put into the pipette pit (so to speak) the University of Michigan-Flint against the University of Detroit Mercy. The field has since grown to 12 schools, with Kalamazoo College joining in 2012. Competition consists of several activities that test a team’s knowledge and skill as it pertains to different chemistry concepts. All activities are team based (each with 4 or more students) and are scored and ranked based on time or accuracy. Morning prelims are followed by the afternoon’s “playoffs mode,” with only one team taking home the hardware.
Josh Abbott was the only returning K “letter winner” from last year’s sixth-place team. He vowed then that K would be well represented this year and wrote immediately after this winter’s competition to Dr. Truss: “I would just like to let you know we brought some hardware back for Dow.” Sweet!
Professor of Chemistry Laura Furge has received a renewal of her National Institutes of Health (NIH) grant to support continued research in the area of drug-drug interactions. She will conduct this research with undergraduate science students at Kalamazoo College. Adverse drug-drug interactions are common among individuals who take multiple drugs (both over the counter and prescribed), particularly among older persons and among individuals whose bodies express variants of drug metabolizing (drug processing) enzymes. The research in the Furge lab will benefit human health by adding to the understanding of how certain classes of drugs may interact in individuals and cause drug-drug induced unfavorable medical events. Furge currently has five research students working in her lab and has mentored two dozen in her lab and many more in her classes over the past 13 years at K. Funding from the NIH will help ensure continued research opportunities for future generations of scientists. The grant will provide $225,000 over three years.
Scientific presenters at the West Michigan Regional Undergraduate Science Research Conference included (l-r): Carline Dugue, Josh Abbott, Amanda Bolles, Mara Livezey, Kelly Bresnahan, and Chelsea Wallace. Not pictured are Erran Briggs, Michael Hicks, Nicolas Sweda, and Associate Professors of Chemistry Laura Lowe Furge and Regina Stevens-Truss.
Nine Kalamazoo College science majors and two chemistry department faculty members (Regina Stevens-Truss and Laura Lowe Furge) attended the recent West Michigan Regional Undergraduate Science Research Conference in Grand Rapids. The students were Carline Dugue ’12, Chelsea Wallace ’13, Nicholas Sweda ’12, Mara Livezey ’13, Michael Hicks ’12, Kelly Bresnahan ’12, Josh Abbott ’12, Amanda Bolles ’14, and Erran Briggs ’14. Hicks and Wallace are biology majors; the others are majoring in chemistry. They presented results of their summer and academic year research experiences, including Senior Individualized Project work for Dugue, Bresnahan, Sweda, and Abbott. More than 170 posters from colleges across West Michigan were part of the conference’s poster session, and some 400 people participated in the conference. Dugue’s research focused on semiconductor quantum dots and charge transfer; she worked with Western Michigan University professor Sherine Obare. Abbott’s work focused on the role of a specific liver enzyme (CYP2B6) in the way the body processes the cancer drug cyclophosphamide. He did this work in the lab of Professor Paul Hollenberg at the University of Michigan. Bresnahan completed her SIP at the University of Michigan laboratory of Professor James Woods. She worked on animal models for testing of molecules called cholinergic receptor agonists for aid in smoking cessation studies. The other six posters described research done at Kalamazoo College. Sweda presented ongoing studies from Professor Stevens-Truss’s lab on suramin selective inhibition of nitric oxide synthases, part of a chain of events that affects production of nitric oxide in the human body. An excess of nitric oxide is associated with conditions such as Parkinson’s disease and Alzheimer’s disease. This work is the basis of a manuscript in preparation with Sweda and Alyssa McNamara ’11 as co-authors. Wallace’s research (with Associate Professor of Biology Blaine Moore) showed that BCL-2 is able to rescue neuroblastoma cells from ethanol toxicity. Livezey, Hicks, Bolles, and Briggs each presented individual posters with results of three projects from Professor Furge’s lab on the interactions of inhibitors with human cytochrome P450 enzymes. These enzymes metabolize compounds, including medicines, in the liver, and the inhibition of those enzymes may influence the effectiveness of current and new medicines. The work presented by Bolles and Briggs is currently being prepared in a manuscript for publication with both students as co-authors along with Livezey. The posters presented by Hicks and Livezey are the basis of a current NIH grant renewal to support ongoing opportunities for student research in the Furge lab. In addition to the poster sessions, students attended several lectures and were able to meet with graduate school recruiters.
Cassandra Fraser, Class of 1984, is a chemistry professor at the University of Virginia. This summer she hosted Michael Paule-Carres, Class of 2014, in her laboratory, where he did research for his Senior Individualized Project. “It was kind of scary to contemplate that 30 year gap!” wrote Fraser, who had a good antidote for any mild “gap fear.” The formula included the excellence of the lab work Paule-Carres conducted. “He synthesized and characterized a luminescent polymer that will be used to make oxygen nanosensors for wound diagnostics, tumor hypoxia imaging, and other medical uses,” Fraser explained. And for extra measure, a few funny photos were added. “We took some research group pictures, including some of Mike (right) and me together, the Kalamazoo College chemists. We even attempted to make K’s with our bodies, not so successfully mind you, but maybe it’s the thought that counts.” Mike has returned to campus for the beginning of men’s varsity soccer practice.
Nahrain Kamber ’01 is an associate scientist and solutionist at Dow Chemical Company. She describes her scientific journey on YouTube. Today she applies discoveries in polymer chemistry to the creation of new products for people.
In addition to Associate Professor of Chemistry Laura Furge, the senior and corresponding author, the manuscript has six student co-authors: Mara Livezey ’13, Leslie Nagy ’09, Laura Diffenderfer ’11,Evan Arthur ’09, David Hsi ’10, and Jeffery Holton ’13.
Their work described in this paper contributes to the understanding of how some drugs can halt the activity of an enzyme. In this case, the enzyme studied is one that is important for the body’s processing of about 20 percent of medicines, particularly treatments for arrhythmia and other heart diseases, depression, and other maladies. Such understanding is vital because many people’s health depends on daily regimens of multiple medicines. Sometimes one drug can interfere with the very enzymes responsible for the processing and clearance of other co-administered drugs. This and other unwanted side effects are the number one cause of hospitalization in America.
The paper’s contribution to the understanding of how certain classes of drugs cause this interference with key enzymes will hopefully lead to more effective prevention of the phenomenon in the future.
The K research was funded by grants from the National Institutes of Health and the Howard Hughes Medical Institute and by the Department of Chemistry Hutchcroft Fund. The latter was established by a gift from alumni Alan ’63 and Elaine (Goff) Hutchcroft ’63.
The final version of the study was presented at the San Diego meeting of the American Society for Biochemistry and Molecular Biology.
Professor Furchak in the Dow Science Building with Kalamazoo chemistry majors (l-r) Vinay Sharma ’12, Lydia Manger ’13, Eric Glanz ’13, and Amy Ong ’11
Herbert H. and Grace A. Dow Assistant Professor of Chemistry Jennifer R. Furchak has received a 2011 Cottrell College Science Award from the Research Corporation for Science Advancement. She will use the $35,000 award to further her work into the development of a multiplexed assay for the analysis of breast cancer metastasis.
“The potential impact of this work in detection and understanding of breast cancer metastasis lies in improvements in simplicity, accuracy, and speed over current methods, which could allow for improved patient treatment and prognoses,” she said. “Ultimately, additional sample throughput will result in better understanding of disease progression.”
According to Furchak, five student researchers at “K” have worked on this project thus far. It’s been the foundation for three completed Senior Independent Projects, and another is in progress this summer. Furchak’s grant is one of 48 Cottrell grants this year totaling $1.8 million and intended to support early career scientists at liberal arts colleges and primarily undergraduate universities.
Undergraduate students must be involved in the research in meaningful ways. Founded in 1912, Research Corporation for Science Advancement is the second-oldest foundation in the United States and the oldest foundation for science advancement.
Seniors Aidan Klobuchar and Niclas West presented posters describing their Senior Individualized Project research at the 59th annual Western Spectroscopy Association Meeting at the Asilomar Conference Center in Pacific Grove, California, in January.
Klobuchar worked on the project “Revealing Orientation Using Circularly Polarized Light” with Associate Professor of Chemistry Jeff Bartz. West based his poster, “Revealing Molecular Dynamics Through DC Slice Ion Imaging,” on his research with Professor Simon North at Texas A&M University. Both students have worked with Professor Bartz on laser-based research since Summer 2008. Klobuchar and West will attend graduate school in physical chemistry this fall.
Vicky Minderhout ’72, a professor of chemistry at Seattle University, was named the State of Washington’s “Professor of the Year” by the Carnegie Foundation for the Advancement of Teaching. She was one of 27 state-level winners in 2011; four others were national-level winners. Minderhout was cited for her innovations in teaching, particularly biochemistry.
“Her research in Process Oriented Guided Inquiry Learning as applied to biochemistry has been a national model for many years now,” said Associate Professor of Chemistry Laura Furge,“I have met Vicky many times, and always introduce my students to her when we see her at the American Society for Biochemistry and Molecular Biology meetings.”
ASBMB’s newsletter, ASBMB Today, published an interview with Minderhout in which she was questioned about teachers who influenced her classroom methods. In her answer she describes a quantum mechanics class that was taught by Associate Professor of Chemistry Ralph Deal. She also cites the enthusiasm that characterized Professor of Chemistry Kurt Kaufman’s interactive lectures. King TV in Seattle did a feature story on Minderhout’s Socratic style that includes the voices of many of her students.
