faculty

Challenge and Imagination: Working Science at K

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Kalamazoo College alumnus Parker de Waal
Parker de Waal ’13

Parker de Waal ’13 had a wish: he wanted to work on a computational chemistry project.

Laura Furge, the Roger F. and Harriet G. Varney Professor of Chemistry, had a challenge: she needed models of the variants of an important human enzyme. (Some background: The aforementioned enzyme, found in the liver, helps the body process medicines, but it’s not exactly the same–hence, variants–in all individuals. Such variability means some people react differently (including adversely) to important medicines. That’s a serious health problem, and part of Furge’s current grant from the National Institutes of Health calls for the study of these variants. And for such study a model of the variants’ structures would certainly be useful!)

In spring 2013, wish met challenge, and, one year later, the two researchers (along with co-author Kyle Sunden ’16) have published a paper in PLoS ONE, the online journal of the Public Library of Science.

That culminating publication traces back to a laboratory question: Could de Waal (a student in Furge’s “Advanced Biochemistry” class) make computational models of the variants? “I suggested some different ways to approach the problem,” says Furge, “and those approaches took Parker all of about two days!” It was at that point that de Waal suggested to Furge some different, more powerful computational approaches–specifically, molecular dynamics using more sophisticated software. “I said, ’Let’s go for it!’” says Furge. “And we both started on the journey to learn more about Molecular Dynamics approaches.”

The journey included consulting with other scientists around the country and the world (Germany, the Czech Republic) both by email and in person at various scientific conferences. Furge and de Waal used a supercomputer at the University of Texas for the computational work. Analysis of the resulting structures was completed by Furge and Sunden during the winter and spring terms of 2014. “The project is a beautiful example of how research and teaching go together at K,” says Furge. The work has been presented at two major medical meetings.

The paper includes 21 figures and tables. Parker de Waal performed all the experiments that led to the figures; Sunden did the experiments and analyses for two of the figures. Furge did the majority of the analysis. In true liberal arts fashion, the cross-disciplinary work combines computer science and biochemistry. Furge taught Sunden, a chemistry and computer science double major, the relevant biochemistry as they progressed with the project. Sunden hopes to continue the work for his Senior Individualized Project after he returns from study abroad in Australia. The work may one day contribute to personalized solutions for people who have adverse drug reactions to important medicines. The paper has had more than 300 views in the six weeks since it’s been published.

Great academics, cross-disciplinary collaboration, research at the edge, and science that matters! Science education at Kalamazoo College: a double helix of challenge and imagination.

K on the Art Hop this Friday, Nov. 7

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The Birds of Great Britain
“Nyctea Nivea.” Plate from John Gould’s “The Birds of Great Britain, London, 1862-1873.

Even if you don’t know much about art, there will be plenty to like this Friday, Nov. 7, 5-8 p.m., when K students, faculty, and the campus itself participate in the monthly Art Hop in downtown Kalamazoo.

“John Gould’s Glories” features beautiful images from the College’s permanent collection by this renowned 19th English ornithologist and artist. Aided by his wife, Elizabeth, Gould published numerous monographs and illustrations of birds from around the world. His famous “Darwin’s finches” played a key role in Charles Darwin’s theory of evolution by natural selection.
5-8 p.m. – A.M. Todd Rare Book Room, Upjohn Library (third floor), 150 Thompson St., Kalamazoo College

The Miller-Johnson Art Scholarship and Exhibition for K students concludes in the Park Trades Center. Earlier this year, a jury of K art faculty selected artwork by K students Donna Aguilar ’15, Zoe Beaudry ’14, Lauren Gaunt ’15, and Gabe Montesanti ’15 to be displayed in the lobby of Miller-Johnson Attorneys and Counselors in downtown Kalamazoo. Each student also received $150 from Miller-Johnson. This Friday, the public may vote on their favorite among the four, with the top vote-getter receiving an additional $400! THANK YOU, MILLER-JOHNSON, for supporting Kalamazoo College student artists!
5-8 p.m. – K Community Art Studio, Room 312 (third floor), Park Trades Center, 326 W. Kalamazoo Ave.

More K faculty and student art will be on display from 5-8 p.m. in the Park Trades Center (326 W. Kalamazoo Ave.), including:

  • An exhibit of artwork from the current K Advanced Studio class: Room 312
  • An installation by studio art major Cheyenne Harvey ’15 that explores the individual and social demarcations of “in/out” through use of video and mixed media sculpture: Room 411B
  • An exhibition of K student artwork of all levels organized by the College’s “Arts in the Community Living Learning House”: Room 209L
  • Artwork by Department of Art faculty Tom Rice and Sarah Lindley in the K Faculty Studio: Room 405A.

K Professor and Students Publish Important Chemistry Research

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K students Rina Fujiwara, Erran Briggs and Amanda Bolles with Professor Laura Furge
Medicinal researchers and members of the Furge Lab (l-r): Rina Fujiwara, Erran Briggs, Amanda Bolles, and Laura Furge

Laura Furge, the Roger F. and Harriet G. Varney Professor of Chemistry at Kalamazoo College, is the senior and corresponding author of an important scientific paper that includes three Kalamazoo College student co-authors: Amanda Bolles ’14, Rina Fujiwara ’15, and Erran Briggs ’14. The paper is titled “Mechanism-based Inactivation of Human Cytochrome P450 3A4 by Two Piperazine-containing Compounds” and appears in Drug Metabolism and Disposition, a highly regarded, high impact international journal published by the American Society for Pharmacology and Experimental Therapeutics. The research the paper describes, which was conducted in the Furge Lab on K’s campus, contributes the understanding of how some drugs “apply the brakes to” the activity of an enzyme–in this particular case, an enzyme important to the metabolism (or processing) of about half of all medicines! What are the human implications of the work? “Many individuals take multiple medicines each day,” said Furge. “Multiple-drug regimens can lead to unwanted side effects, including drug-induced inhibition of the very enzymes responsible for the metabolism and clearance of other co-administered drugs.” In fact, side effects from drug interactions of polypharmacy therapy are the number one cause of hospitalization in the U.S. “This paper adds in understanding of how certain classes of drugs may cause this type of unfavorable medical event,” said Furge. “New insights will hopefully lead to better prevention in the future.”

The paper includes 13 figures and tables. Furge noted that Bolles, Fujiwara, and Briggs performed all the experiments that lead to those figures, and “all the work was done on the campus at Kalamazoo College. We had all the equipment here needed to complete these studies, and we have already started full swing on another set of experiments for a future publication.” The students have presented parts of the preliminary data at national meetings in the past year, and the research forms of basis of the Senior Individualized Projects for Bolles and Fujiwara.

Such research, and the extraordinary educational opportunities it provides for K students, requires the cooperation, coordination, and collaboration of many funding sources. “This is so important,” Furge stressed. The Richard Cook Fellowship and the Alan and Elaine Hutchcroft Fund (endowments created and supported by alumni gifts) paid for the summer stipends of Fujiwara and Bolles, respectively. The mass spectrometer essential to the experiments was paid for in part by the Hutchcroft Fund and a grant from the Howard Hughes Medical Institute. The research also was funded by grants Furge secured from the National Institutes of Health.

“Drug Metabolism and Disposition is an international journal with a high impact factor,” added Furge. Impact factors measure how frequently manuscripts in a journal are referenced by other authors.

Baby Tears and Dancing Twins

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Kalamazoo College Psychology Professor Siu-Lan TanPsychology Press has launched a new social media campaign called “Ask Dr. Tan.” And, yes, it’s “our” Dr. Tan–Professor of Psychology Siu-Lan Tan. Psychology Press is one of her publishers. Their Twitter account has many followers (among the highest number of any academic press). To celebrate having surpassed 50,000 followers, Psychology Press asked Siu-Lan to do #ASKDRTAN.

They chose wisely. Even though Siu-Lan confessed (in a recent BeLight article) to being a neophyte in the world of social media, her blog about a baby moved to tears by her mother’s singing was an incredibly successful “must-read” on two popular blogs in 2013. Psychology Press has launched its Twitter campaign with videos of twin girls dancing to their father’s guitar at ages 1, 2, and 3. The videos had gone viral, and #ASKDRTAN invites denizens of the blogosphere and Twitterverse to ask Siu-Lan any questions that come to mind about the girls’ behavior and their early responses to music. Example: What do most infants respond to first in music: melody or rhythm?

Siu-Lan will receive all questions before October 29 via Psychology Press’s Twitter and Facebook accounts. Submitters of questions deemed top picks get a prize (a free copy of her book, Psychology of Music: From Sound to Significance). Top pick questions will be developed as part of an article that will appear on the Psychology Press website and on Siu-Lan’s Psychology Today blog, What Shapes Film?

Philharmonia Director Wins Music Award

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Associate Professor of Music Andrew KoehlerAssociate Professor of Music Andrew Koehler, who also serves as music director of the Kalamazoo Philharmonia, is the 2014 winner of The American Prize in Orchestral Programming—Vytautas Marijosius Memorial Award—in the community division. Andrew was selected from applications reviewed this summer from all across the United States. The American Prize is a series of new, non-profit competitions unique in scope and structure, designed to recognize and reward the best performing artists, ensembles and composers in the United States based on submitted recordings. The award honors the work of Vytautas Marijosius, who served for 35 years as director of orchestral activities at the Hartt School of Music of the University of Hartford. Andrew has appeared as a guest with the West Michigan Symphony; the Lyatoshynsky Chamber Orchestra in Kyiv, Ukraine; and the Festival South Chamber Orchestra in Mississippi, among others. Recently, he took part in the 9th Grzegorz Fitelberg International Conductor’s Competition in Katowice, Poland, where he won First Distinction and the Youth Jury Prize. Andrew is a graduate of Yale College, where he completed a B.A. in music and German studies (graduating with honors and distinction in both majors). He holds a certificate in conducting from the Universität für Musik und Darstellende Kunst in Vienna, where he studied for two years as a Fulbright scholar, as well as a Master’s degree from Northwestern University.

Rolling Through…Time?

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Professor of Psychology Siu-Lan Tan’s latest blogProfessor of Psychology Siu-Lan Tan’s latest blog–“Rolling Through Time“–reunites her with former K student John Baxa in a conversation about an animated short feature John helped create. That short is titled “Ball” and is about time. Or is it memory (its power and limitations)? Or aging? Play or death?  All this in a three-minute animated short? Of course, suggests Siu-Lan and John. It’s a matter of layers (certainly a part of What Shapes Film) as well as all that a viewer brings to the experience (the story is in the eye of the beholder). Enjoy your own encounter, to which you bring…what?

Three or four viewings evoked for me two poems, one by Wislawa Szymborska and the other by K’s own Con Hilberry. The poems are related to each other and to the animated short, though the three differ, especially in the feeling of their endings. The poems are shared below.

John graduated from K in 2009. He majored in psychology and earned a concentration in media studies. He recently completed a Master’s degree in entertainment technology at Carnegie Mellon. His short has no speech or text. Layers of image and music are everything. The music, somewhat ironically, is titled “Words.”

Still Life With a Balloon
(by Wislawa Szymborska, from Poems New and Collected 1957-1997, Harcourt, Inc., 1998)

Returning memories?
No, at the time of death
I’d like to see lost objects
return instead.

Avalanches of gloves,
coats, suitcases, umbrellas—
come, and I’ll say at last:
What good’s all this?

Safety pins, two odd combs,
a paper rose, a knife,
some string—come, and I’ll say
at last: I haven’t missed you.

Please turn up, key, come out,
wherever you’ve been hiding,
in time for me to say:
You’ve gotten rusty friend!

Downpours of affidavits,
permits and questionnaires,
rain down and I will say:
I see the sun behind you.

My watch, dropped in a river,
bob up and let me seize you—
then, face to face, I’ll say:
Your so-called time is up.

And lastly, toy balloon
once kidnapped by the wind—
come home, and I will say:
There are no children here.

Fly out the open window
and into the wide world;
let someone else should “Look!”
and I will cry.

Memory
(by Conrad Hilberry, from Until the Full Moon Has Its Say, Wayne State University Press, 2014)

Everything that was—touch
football in the street, Peggy

McKay in the hay wagon,
Miss LaBatt’s geometry, the second

floor in Madison, where
one daughter slept in a closet.

Is any of this true? Nightgowns,
glances, griefs existing nowhere

but in this sieve of memory.
Newspaper files, bank accounts,

court records—nothing there.
It’s gone, except for these scratchy

words—blackbird on a branch,
long story caught in his throat.

Hornet “Senior” Mitch Wilson Tests His Mettle in National Golf Tourney

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Kalamazoo College men's golf coach Mitch Wilson
Hornet Men’s Golf Coach Mitch Wilson

Kalamazoo College Men’s Golf Coach Mitch Wilson had a good summer playing the sport. He was on the winning team in the Golf Association of Michigan (GAM) vs. Golf Association of Ontario tournament. He won the club championship at The Moors golf club in Portage, Mich. He made it to the semifinals of the GAM Michigan Senior Match Play. And he finished third in the Michigan Senior Open.

Hard to top that! And yet the 57-year-old is having an even better fall.

In the recent U.S. Senior Amateur played at Big Canyon Country Club in Newport Beach, Calif., Wilson shot a seven-over-par 151 (76-75) to miss by just two strokes making the top 64 and qualify for the match play portion of the tournament. It’s the first time he’s ever played in the event operated by the United States Golf Association (USGA).

“Was I happy with my scores? Well, no,” Wilson said with a smile. “I would like to have three shots and one putt over.

“I made three double bogeys, two on the first day and one on the second day, and all of them were preventable. The rest of the tournament was pretty good.”

The local veteran golfer, who has played national tournaments before, (including the USGA’s U.S. Mid-Amateur (for players 25 and older) in 1998 and 2000), still had that nervous feeling on the first tee at the Senior Amateur.

“As much experience as you have in events like this, you still have those first-tee nerves,” he said. “I had enough birdies, but I made a few bad mistakes and it cost me.”

What Wilson has found is that there are a lot of very good golfers in the 55-over set. However, it’s a different mindset.

“It’s not as intense as a senior and you understand it’s not the end of the world,” he said. “It’s a real pleasure to play in these events and become reacquainted with guys you haven’t seen in a while.”

He’s been able to work on his golf game a little more than usual this summer. He retired as the executive director of Pretty Lake Camp near Kalamazoo this past March.

“I’m going to take a year to see how things are going, possibly do some consulting,” Wilson said.

He keeps busy by being on the board of the First Tee of Battle Creek, a nonprofit organization that teaches life skills and leadership through the game of golf, and coaching the Hornet men who are having one of their better seasons of late.

Looking at his tournament results this summer, the extra work has paid off.

Story by Paul Morgan

Jewish Studies Program Sponsors Panel Discussion

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Director of Jewish Studies Jeff Haus
Director of Jewish Studies Jeff Haus speaking with students

On Wednesday, October 29, at 7:30 p.m., the Jewish Studies program at Kalamazoo College will host a panel discussion titled, “Boycott Divestment Sanctions: Alternative Narratives.” The discussion will take place in the Mandelle Hall Olmsted Room and is free and open to the public. This program will add to the campus discussion of the issue of boycotts and divestment targeting Israeli companies and academics by placing the current conflict between Israel and the Palestinians into a broader political and historical context. The panel will also consider the implications of some of the rhetoric surrounding the BDS movement.

Participants include historian Kenneth Waltzer and political scientist Yael Aronoff, both members of the Jewish Studies program at Michigan State University (Aronoff is the present director of the program, and Waltzer is her immediate predecessor), and political scientist Amy Elman, the Weber Professor in Social Science at Kalamazoo College. Both Waltzer and Aronoff will consider the issue of Jewish self-determination (which is often left out of BDS discussions), and provide a critical assessment of BDS and its implications. Elman’s presentation will discuss her recent research on the European Union and its policies toward Israel and Jews, and the inherent contradictions contained therein. Jeffrey Haus, director of Jewish Studies at Kalamazoo College, will moderate the program, which will also include a question and answer period for the audience.

Paper’s Tops at Conference

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Amy MacMillan among three receiving awardsAmy MacMillan, the L. Lee Stryker Assistant Professor of Business Management, co-authored a paper titled “Improving the Collaborative Online Student Evaluation Process”—a research effort so fine it received the award for Best Conference Refereed Paper from the Marketing Management Association. The award was presented at a lunch during the MMA conference in San Antonio, Texas. Amy wrote, “I am enjoying representing Kalamazoo College at this conference, attended by hundreds of marketing educators, as well as industry experts and journal editors. From teaching ideas to research strategies technology tools, there are many things I’m excited to bring back to campus.” The financial support to attend the conference is part of the endowed professorship that Amy holds. That aspect of endowed professorships–the encouragement of faculty learning and scholarship–is one reason they are so important and a primary focus of The Campaign for Kalamazoo College. Amy (at left) is pictured with two of the paper’s co-authors (both from Western Michigan University). The fourth co-author teaches in China.

With/Out ¿Borders? Opens Thursday

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Two social justice advocates attend Without Borders ConferenceMore than 500 social justice advocates, scholars and leaders ranging from civil rights icons and eccentric artists to young organizers and poet laureates will be on the Kalamazoo College campus, as well as locations throughout the city, this weekend, Sept. 25-28 to participate in the Arcus Center for Social Justice Leadership (ACSJL) “With/Out ¿Borders?” conference.

Attendees will engage in questioning–and openly attempt to complicate –the political, ideological, cultural, and social barriers that make up our world. Thought-provoking plenary sessions, participatory think tanks, and moving and entertaining artistic performances are just some of the diverse and engaging platforms that will be used to question the borders that surround so much of our world today–and develop paradigms and strategies to break them down.

Well-known performance artists and cultural workers Guillermo Gómez-Peña and Michèle Ceballos Michot, whom make up the performance troupe La Pocha Nostra, will be on stage on Friday afternoon with Adriana Garriga-López, the Arcus Social Justice Leadership Assistant Professor of Anthropology. The trio will discuss, instigate, and agitate on the meaning of border politics, performance, and the role of art in the process.

Later that day, the conference will take on a more poetic note, as two well-known poets read form their work and engage with local poet and activist Denise Miller and Lisa Brock, academic director of the ACSJL.

Nikki Finney, winner of the 2011 National Book Award for Poetry, and Keorapetse “Willie” Kgositsile, former poet laureate of South Africa, will bear witness to history and exile and set the stage alive with “truth telling” and love poems crafted out of the struggles of black people from both the southern areas of the United States and South Africa.

Civil rights icon Angela Davis will take to the stage on Saturday morning, along with distinguished African American studies expert Robin D. G. Kelley, peace activists Lynn Pollack and Leenah Odeh and academics Alex Lubin and Saree Makdisi, to discuss the Boycott, Divest and Sanction (BDS) Movement emerging globally in support of the Palestinian people, who live in walled, or “bordered” territories.

Participants in this plenary session will ask if the BDS movement is the next critical solidarity movement of our time, who it’s for, who it’s against, and why.

Cities will take center stage later Saturday, when a plenary of scholars and organizers examine resistance movements in cities today. Organizer and writer Kali Akuno, Detroit-based activist shea howell and David Stovall, professor of African-American studies, will discuss teacher protests in Chicago, water rights issues in Detroit, city planning strategies in Jackson, Miss., and minimum-wage increase advocacy efforts nationwide at this plenary moderated by Rhonda Williams, associate professor of History at Case Western University.

The future of various social justice movements will be on display in the Hicks Center Banquet Room Sunday morning, where a host of young social justice advocates and organizers will discuss their own projects, talk about the need for more youth to become involved and analyze the New Youth Movement.

Civil rights organizers Phillip Agnew and Charlene Carruthers, undocumented immigrant advocate Lulu Martinez, climate change organizer Will Lawrence, sexual assault awareness organizer Zoe Ridolfi-Starr and voting rights advocate Sean Estelle will be in on the discussion, moderated by the Mia Henry, executive director of the ACSJL.

For a full list of events, go to the conference’s schedule page.