research

The Magnificent Five

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Five women representing Kalamazoo College
(Left to right) Regina Stevens-Truss, Lindsey Gaston, Sandrine Zilikana, Laura Lowe Furge, and Mara Livezey

Majors Sandrine Zilikana ’12 and Mara Livezey ’13 and biology major Lindsey Gaston ’12  joined chemistry department faculty members Regina Stevens-Truss and Laura Lowe Furge at the American Society for Biochemistry and Molecular Biology Meeting in San Diego in late April. The students presented results of their summer research experiences (part of the Senior Individualized Projects for Sandrine and Lindsey) as part of both the Annual Undergraduate Poster Competition and the regular scientific sessions of the meeting.

More than 200 students from schools across the country were part of the undergraduate poster competition.  Zilikana’s research measured differences in reducing the potential of cancer cell types to affect drug delivery. She conducted this scientific work at the University of Michigan with Professor Kyung-Dall Lee.  Gaston’s showed that a specific hormone prevented nerve cell death after brain injury. Her research, conducted with Professor Vishal Bansal at the University of California-San Diego, will be included in a manuscript just accepted to the Journal of Neuropathology and Experimental Neurology. Livezey presented the results of a study she has worked on for the past two years in Furge’s lab modeling the interactions of inhibitors with human cytochrome P450 enzymes. That study was recently published in Drug Metabolism Letters. While in San Diego, Stevens-Truss directed a teaching workshop for middle school and high school science teachers in the San Diego area. Her innovation in development of the workshop has drawn increasing numbers of teachers to the workshop and provided a new platform for scientists to collaborate with and mentor the nation’s secondary school science teachers.

The workshop was funded by a grant from the National Science Foundation. Next year’s meeting will be in Boston, and Stevens-Truss and Furge plan to attend with another group of students. Stevens-Truss will also lead another teaching workshop there.

Interference Implications

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Kalamazoo College student at a conference in San Diego
Mara Livezey discussing the work with other scientists in San Diego.

The peer-reviewed publication Drug Metabolism Letters has accepted for publication the manuscript “Molecular Analysis and Modeling of Inactivation of Human CYP2D6 by Four Mechanism Based Inactivators.”

In addition to Associate Professor of Chemistry Laura Furge, the senior and corresponding author, the manuscript has six student co-authors: Mara Livezey ’13, Leslie Nagy ’09, Laura Diffenderfer ’11,Evan Arthur ’09, David Hsi ’10, and Jeffery Holton ’13.

Their work described in this paper contributes to the understanding of how some drugs can halt the activity of an enzyme. In this case, the enzyme studied is one that is important for the body’s processing of about 20 percent of medicines, particularly treatments for arrhythmia and other heart diseases, depression, and other maladies. Such understanding is vital because many people’s health depends on daily regimens of multiple medicines. Sometimes one drug can interfere with the very enzymes responsible for the processing and clearance of other co-administered drugs. This and other unwanted side effects are the number one cause of hospitalization in America.

The paper’s contribution to the understanding of how certain classes of drugs cause this interference with key enzymes will hopefully lead to more effective prevention of the phenomenon in the future.

The K research was funded by grants from the National Institutes of Health and the Howard Hughes Medical Institute and by the Department of Chemistry Hutchcroft Fund. The latter was established by a gift from alumni Alan ’63 and Elaine (Goff) Hutchcroft ’63.

The final version of the study was presented at the San Diego meeting of the American Society for Biochemistry and Molecular Biology.

Jamie Grant Co-Authors Gender Article in LGBTQ Policy Journal

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Jaime Grant, executive director of the Arcus Center for Social Justice Leadership, has coauthored an op/ed in the May 15 Huffington Post that describes “A Gender Not Listed Here: Genderqueers, Gender Rebels, and OtherWise,” an article she and her coauthors recently published in the Harvard Kennedy School’s LGBTQ Policy Journal.

Grant and coauthors Jack Harrison and Jody L. Herman present new research focused specifically on genderqueer people and describes the risks and resiliencies of those who identify outside the male/female gender binary. Their Policy Journal article shows that genderqueer people have unique demographic characteristics and experiences of discrimination and violence when compared to transgender people who identify as “male” or “female.”

Science Grant Benefits Breast Cancer Research

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Professor Furchak at Dow with four chemistry majors
Professor Furchak in the Dow Science Building with Kalamazoo chemistry majors (l-r) Vinay Sharma ’12, Lydia Manger ’13, Eric Glanz ’13, and Amy Ong ’11

Herbert H. and Grace A. Dow Assistant Professor of Chemistry Jennifer R. Furchak has received a 2011 Cottrell College Science Award from the Research Corporation for Science Advancement. She will use the $35,000 award to further her work into the development of a multiplexed assay for the analysis of breast cancer metastasis.

“The potential impact of this work in detection and understanding of breast cancer metastasis lies in improvements in simplicity, accuracy, and speed over current methods, which could allow for improved patient treatment and prognoses,” she said. “Ultimately, additional sample throughput will result in better understanding of disease progression.”

According to Furchak, five student researchers at “K” have worked on this project thus far. It’s been the foundation for three completed Senior Independent Projects, and another is in progress this summer. Furchak’s grant is one of 48 Cottrell grants this year totaling $1.8 million and intended to support early career scientists at liberal arts colleges and primarily undergraduate universities.

Undergraduate students must be involved in the research in meaningful ways. Founded in 1912, Research Corporation for Science Advancement is the second-oldest foundation in the United States and the oldest foundation for science advancement.

Five “K” Students Compete in Poster Presentation for ASBMB

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Five Kalamazoo College students
Left to Right: Popli, Nagy, Diffenderfer, Parson, and McNamara

Kalamazoo College enjoyed a strong scientific presence at the Washington, D.C. meeting of the American Society for Biochemistry and Molecular Biology (ASBMB). Associate Professor of Chemistry Laura Furge served as a judge in the 15th Annual Undergraduate Poster Competition, in which five “K” students competed against more than 200 other undergraduates from throughout the country.

Laura Diffenderfer ’11 presented a poster titled “Autodock as a method for predicting binding for substrates and inhibitors of human cytochrome P450 2D6,” based on a sliver of the research she’s conducted for the past two years in Furge’s lab. Diffenderfer plans to attend Wayne State Medical School this fall. Alyssa McNamara ’11, a four-year denizen in the lab of chemistry professor Regina Stevens-Truss, presented “Suramin discriminates between the calmodulin-binding sites of neuronal and inducible nitric oxide synthase.” She will work for the Schuler Family Foundation in Chicago before she enrolls in medical school in 2012.

Leslie Nagy ’09 and Diffenderfer presented “Mechanism-based inhibition of human cytochrome P450 2D6 by Schering 66712,” work recently accepted for publication in Drug Metabolism and Disposition. Nagy is completing a two-year appointment as a laboratory research associate in Furge’s lab.

Tanav Popli ’11 presented a poster based on his SIP work at University of California-San Francisco. His poster was titled “Tmtc4 interacts with C3G, Wntless, and Zfhx4: a yeast two-hybrid trap for proteins associated with development of the corpus callosum.” Tanov plans to work in a laboratory after graduation and then apply for an M.D./Ph.D. program.

Emily Parson ’11 presented a poster titled “Characterization of a real time PCR assay for the detection and quantification of Plasmodium malariae parasites.” She did her SIP, which was based in part on her study abroad experience in Kenya, at the Walter Reed U.S. Army Medical Research Unit in Washington, D.C. After she graduates this spring, Emily will return to Walter Reed to continue research in related areas.

“Attendance at a national meeting is a tremendous opportunity for students to hear and meet leading scientists, to see how scientists share ideas with each other, and to see how scientific research accumulates and allows for the formation of new hypotheses,” said Furge.

And it’s an opportunity that depends on philanthropy. Student travel to this meeting was supported by a grant to “K” from the Howard Hughes Medical Institute. Popli received a travel award from the Undergraduate Affiliation Network of Kalamazoo College headed by Stevens-Truss. Stevens-Truss organized the first annual ASBMB workshop titled: “Fostering Partnerships Between Colleges/Universities and Junior High School Teachers,” and she noted that it got off the ground despite her absence due to and airline grounding. “I was disappointed to miss the workshop when my flight was grounded in Kalamazoo,” said Stevens-Truss. “But I’m glad the idea is now a successful reality.”

The second offering of the workshop will occur next April in San Diego.

Professor Emeritus Publishes in Revue Bénédictine

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John Wickstrom, professor emeritus of history, will have an article published by Revue Bénédictine in 2013. It is titled “Claiming St. Maurus of Glanfeuil: an 11th-Century Sermon from Fossés.”

John is also the 2012 Moritz Lecturer at Kalamazoo College. His talk, “Picturing the Saints: What Medieval Illuminations Can Tell us About History,” will be delivered on Wednesday, April 4, at 7 P.M. in Dewing Hall Room 103. The event is free and open to the public.

Professor Barclay Lectures on West Berlin in the Context of Postwar History

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David Barclay, the Margaret and Roger Scholten Professor of International Studies, delivered a lecture titled “Island City, Cold War City: West Berlin in the Context of Postwar History, 1948-1994” at his undergraduate alma mater, the University of Florida.

The presentation was based on his current book project: a general history of West Berlin from the time of the city’s division (1948) to the withdrawal of Russian and Allied troops (1994).

The history of West Berlin—a unique creation of the Cold War, like the two German states themselves—has largely been overlooked.

Barclay’s lecture drew on extensive interviews and years of archival research and argued that, in the wake of the well-known “spatial turn” of the 1990s and thereafter, West Berlin’s role in the history of the Cold War can be understood in terms of that truncated city’s function as political space, symbolic space, and cultural space. Moreover, its history can be divided into two parts: an “heroic” phase from 1948 to 1971-72 and a phase of “abnormal normality” from 1972 to 1989.

Student Researches American Volley Ball Coaches Association

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Colleen Leonard class of 2012
Colleen Leonard ’12

Colleen Leonard ’12 examines results from the first-ever salary survey conducted by the American Volleyball Coaches Association (AVCA) in the February/March 2012 issue of Coaching Volleyball, an AVCA publication.

She drew valuable conclusions from coaches at all levels of NCAA competition for “Money Talks: AVCA Salary Survey Analysis,” an article she researched and wrote as part of her Senior Individualized Project at K.

Colleen is an economics major with minors in math and art from Mason, Mich. who studied abroad in Strasbourg, France and interned with AFLAC in East Lansing. She was an outside hitter on the Hornet volleyball team for four years, earning All-MIAA First Team honors as a junior and senior, Second Team as a sophomore. She also traveled to China with her Hornet team in 2009. Well done, Colleen!

SIPs into Published Works: Alumni Collaborate in Research

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When alumni mentor seniors doing their Senior Individualized Projects it can lead to co-authorship of published papers. The proof: Rebecca (Becky) Tonietto ’05 and Katherine (Katie) Ellis ’09. The two are coauthors of the paper “A comparison of bee communities of Chicago green roofs, parks and prairies,” which appeared in the journal Landscape and Urban Planning 103 (2011) 102-108.

Tonietto was a mentor for Ellis during the latter’s SIP, and the published article includes results from Katie’s senior research. Tonietto is working on a Ph.D. in plant biology and conservation at Northwestern University. According to Associate Professor of Biology Ann Fraser, the biology department has many examples of alumni serving as SIP mentors for seniors, “and entomology has been an especially fruitful area for this kind of collaboration,” she added.

SIPs Presented at 59th Annual Spectroscopy Meeting

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Aidan Klobuchar
Niclas West ’12

Seniors Aidan Klobuchar and Niclas West presented posters describing their Senior Individualized Project research at the 59th annual Western Spectroscopy Association Meeting at the Asilomar Conference Center in Pacific Grove, California, in January.

Klobuchar worked on the project “Revealing Orientation Using Circularly Polarized Light” with Associate Professor of Chemistry Jeff Bartz. West based his poster, “Revealing Molecular Dynamics Through DC Slice Ion Imaging,” on his research with Professor Simon North at Texas A&M University. Both students have worked with Professor Bartz on laser-based research since Summer 2008. Klobuchar and West will attend graduate school in physical chemistry this fall.