The Goods are dead, but their good’s alive! Walter and William Good, both members of the Class of 1937, have been deceased from some time, but their legacy lives at the Kalamazoo Air Zoo. The Goods created the Guff, the first successful radio controlled aircraft, and a replica of the aircraft is now on permanent display at the Air Zoo. The aircraft was created with vacuum tube-based control units; it won first place in the 1939, 1940, and 1947 R/C Airplane Nationals. The original plane resides at the Smithsonian National Air and Space Museum. The Good brothers graduated from K with bachelor’s degrees in physics, and they then went on to earn doctorates in the subject.
sciences
K Alumna Wins Prize for Science Journalism
Kirsten Weir ’99 is the winner of the 2012 AAAS Kavli Science Journalism Award in the children’s science news category. The awards are administered by the American Association for the Advancement of Science (AAAS) for professional journalists to honor distinguished reporting for a general audience. Weir received the award for her article “Uninvited Guests,” which appeared in the April/May 2012 issue of Current Health Kids. In a way that appeals to children and adults the article describes the parasites and microbes that live in and on our bodies. Said Weir: “Kids often seem to think that science is something that happens in a laboratory or a faraway place. I loved that this story underscored how much is still unknown about the organisms living right under our noses (not to mention the rest of our bodies).”
Peter Tippett ’75 Wins U.S. Chamber of Commerce Award
The U.S. Chamber of Commerce presented its first Leadership in Health Care Award to Peter Tippett M.D., Ph.D ’75, chief medical officer for Verizon and vice president of the Verizon Incubator. Peter is responsible for Verizon’s health IT strategy and the development of an extensive portfolio of solutions that are enabling the rapidly evolving health care information technology ecosystem. Tippett has worked as an emergency room doctor, as a helicopter emergency physician, and as a virologist. He also worked in software development and is widely credited with creating the first commercial anti-virus product that later became Norton AntiVirus.
K Grad Studies Desert Fish With a Far Eye Cast to Cancer
Claire Riggs ’11 received a pre-doctoral fellowship from the National Science Foundation, a prestigious award that allows her to continue research on killifish embryos as she works on her doctorate at Portland State University. Her research was the subject of an article (“Life in the Extreme”) by Maya Seaman that appeared in the publication, Vanguard. Killifish embryos can survive pretty tough conditions–in extreme heat, without water, and, believe it or not, without oxygen. Riggs studies the role of the fish embryos’ microDNA in their ability to go dormant and survive in anoxic environments. For killifish embryos, such dormancy is characterized by a reduction of metabolism, inhibition of cell development, and stoppage of the heart beat … up to 90 days … without harm! Clues to how this process works, should it ever prove applicable to humans, could eventually have important potential for cancer therapy and treatment of heart attack and stroke.
“I Went to Kalamazoo College!”
Dan Blustein, Joel Haas, and Tess Killpack have a great deal in common. They’re classmates (2006); they’re working on their doctorates; and they’re finalists in a video contest! “Dan entered us in an NSF fellows video contest (of course he did…),” wrote Tess to Professor of Biology Paul Sotherland, “and we made it to the finals.” The contest celebrates the 60th anniversary of the National Science Foundation’s Graduate Research Fellowship Program. Dan, Joel, and Tess share that too; each is an NSF GRF. The title of their video is “Sharing Our NSF GRF Skills With the World.” “We took a little different approach from most of the other entries and did a collaborative entry filming on our own and working over the Internet,” said Dan. “Judges pick winners, and there is one People’s Choice award determined by online votes.” There’s great variety in their research work and geographic dispersion—robot lobsters, cellular energy balance, and avian immune system development, in Boston, San Francisco, and Madison (Wis.) for Dan, Joel, and Tess, respectively. In true K fashion, they do much more than their research. Each works on issues important to science and society, including effective teaching, diversity in the sciences, and scientific policy. Congratulations, Dan, Joel, and Tess. And good luck in the finals.
Kalamazoo Students Intern in Ann Arbor
Several Hornets have settled in Wolverine territory this summer, taking advantage of the resources at a large research university by interning in offices and laboratories throughout Ann Arbor. The Kalamazoo College’s Center for Career and Professional Development caught up with four of them:
Psychology major Megan Martinez ’13 is working to understand links between social, psychological, and physical causes of pain. With the guidance of her supervisor, Ross Halpern, M.D., head of Ross Halpern and Associates Psychiatric Clinic, she is reviewing and analyzing patient files for data connecting childhood abuse, grief, and chronic pain. Martinez said she began her internship thinking that “pain was purely a physical phenomenon, one that should be addressed by doctors and medicine. [However] working in Dr. Halpern’s office has helped me realize that pain, particularly chronic pain, is often influenced by social and psychological factors.” Dr. Halpern has given Martinez plenty of opportunity to take responsibility and guide decision-making on their data project, empowering her to recognize her capacity to conduct independent research and analysis.
Kaitlyn Greiner ’15 is working with Upjohn Professor of Medicine and Oncology Stephen Weiss, M.D., at the University of Michigan Life Sciences Institute to identify mechanisms for invasion and growth of brain tumor cells. One of only a few undergraduates accepted into the Weiss research lab, Greiner said she is “learning valuable techniques and tests that I have no doubt I will need to use in my upper-level biology classes,” and is gaining “a great deal of access to both literature regarding my research and people who are very knowledgeable about what they are researching.” Greiner reports that her time in the Weiss lab has allowed her to practice what she learned in her first-year biology classes and “clarified my desire to do medical research.” Greiner has impressed Dr. Weiss with her curiosity and interest, and has already been invited back to the lab next summer.
Chemistry major Sara Adelman ’14 enjoys talking about K with her alumna supervisor, Nichole Hein ’01, M.D., who is “paying it forward” after her own great experiences with undergraduate summer internships. Dr. Hein is hosting her second K-intern this summer while working as a post-doc in the laboratory of John Fink, M.D., a professor in the Department of Neurology and director of the Neurogenetic Disorders Program in the UM Medical School. In her gene sequencing work this summer, Adelman, who impresses Fink and Hein with her “maturity, independence, and drive,” has found and is double-checking a mutation that might be connected to age-dependent neurologic degeneration. Using her K academics in the lab this summer has helped Adelman recognize that “what I’m learning really has relevance in the real world.”
Kathryn Chamberlain ’13 exudes enthusiasm as she describes her internship in the UM Molecular and Behavioral Neuroscience Institute where she investigates stimuli-induced dopamine release levels with her supervisor, Jennifer Cummings, Ph.D. “It is a learning experience, it is great skill building, and it is opening doors for future opportunities I may have in the field of neuroscience.” Between describing her new-found prowess at building and calibrating carbon fiber electrodes and showing off dozens of graphs of individual experiments using her tiny glass creations to collect data, Chamberlain said her summer work will become part of her Senior Individualized Project at K, and is a pivotal influence in her decision to seek a research career.
Story and photo by Joan Hawxhurst, director, Kalamazoo College Center for Career and Professional Development.
Heyl Scholars 2012
The 2012 Heyl Scholars were honored with a dinner on the Kalamazoo College campus.
The F.W. and Elsie L. Heyl Scholarship awards full-tuition scholarships to graduates of Kalamazoo Public Schools or the Kalamazoo Area Mathematics and Science Center (KAMSC) for the study of nursing at Western Michigan University or science and math at Kalamazoo College. Benefits also include room and board and a book allowance. The scholarship is renewable for up to four years.
Since 1972, the Heyl Scholarship Fund has awarded more than 400 scholarships worth some $30 million.
The Heyl Scholars of 2012 are (l-r): front row—Kelsey Lankford, Kalamazoo Central High School; Yu-Chyn Chiang, Kalamazoo Central High School; Aya Abe, Kalamazoo Loy Norrix High School; second row—Riley Lundquist, Portage Northern High School/KAMSC;Sarah Manski, Vicksburg High School/KAMSC; Kyle Sunden, Gull Lake High School/KAMSC; back row—Paige Maguire, Kalamazoo Central High School/KAMSC;Robert Hudson, Kalamazoo Loy Norrix High School; and Reid Blanchett, Vicksburg High School/KAMSC. Chiang, Abe, Lundquist, Manski, Sunden, Maguire, Hudson, and Blanchett will attend Kalamazoo College. Lankford will attend the WMU School of Nursing. Photo by Anthony Dugal Photography.
The Magnificent Five
Majors Sandrine Zilikana ’12 and Mara Livezey ’13 and biology major Lindsey Gaston ’12 joined chemistry department faculty members Regina Stevens-Truss and Laura Lowe Furge at the American Society for Biochemistry and Molecular Biology Meeting in San Diego in late April. The students presented results of their summer research experiences (part of the Senior Individualized Projects for Sandrine and Lindsey) as part of both the Annual Undergraduate Poster Competition and the regular scientific sessions of the meeting.
More than 200 students from schools across the country were part of the undergraduate poster competition. Zilikana’s research measured differences in reducing the potential of cancer cell types to affect drug delivery. She conducted this scientific work at the University of Michigan with Professor Kyung-Dall Lee. Gaston’s showed that a specific hormone prevented nerve cell death after brain injury. Her research, conducted with Professor Vishal Bansal at the University of California-San Diego, will be included in a manuscript just accepted to the Journal of Neuropathology and Experimental Neurology. Livezey presented the results of a study she has worked on for the past two years in Furge’s lab modeling the interactions of inhibitors with human cytochrome P450 enzymes. That study was recently published in Drug Metabolism Letters. While in San Diego, Stevens-Truss directed a teaching workshop for middle school and high school science teachers in the San Diego area. Her innovation in development of the workshop has drawn increasing numbers of teachers to the workshop and provided a new platform for scientists to collaborate with and mentor the nation’s secondary school science teachers.
The workshop was funded by a grant from the National Science Foundation. Next year’s meeting will be in Boston, and Stevens-Truss and Furge plan to attend with another group of students. Stevens-Truss will also lead another teaching workshop there.
Interference Implications
The peer-reviewed publication Drug Metabolism Letters has accepted for publication the manuscript “Molecular Analysis and Modeling of Inactivation of Human CYP2D6 by Four Mechanism Based Inactivators.”
In addition to Associate Professor of Chemistry Laura Furge, the senior and corresponding author, the manuscript has six student co-authors: Mara Livezey ’13, Leslie Nagy ’09, Laura Diffenderfer ’11,Evan Arthur ’09, David Hsi ’10, and Jeffery Holton ’13.
Their work described in this paper contributes to the understanding of how some drugs can halt the activity of an enzyme. In this case, the enzyme studied is one that is important for the body’s processing of about 20 percent of medicines, particularly treatments for arrhythmia and other heart diseases, depression, and other maladies. Such understanding is vital because many people’s health depends on daily regimens of multiple medicines. Sometimes one drug can interfere with the very enzymes responsible for the processing and clearance of other co-administered drugs. This and other unwanted side effects are the number one cause of hospitalization in America.
The paper’s contribution to the understanding of how certain classes of drugs cause this interference with key enzymes will hopefully lead to more effective prevention of the phenomenon in the future.
The K research was funded by grants from the National Institutes of Health and the Howard Hughes Medical Institute and by the Department of Chemistry Hutchcroft Fund. The latter was established by a gift from alumni Alan ’63 and Elaine (Goff) Hutchcroft ’63.
The final version of the study was presented at the San Diego meeting of the American Society for Biochemistry and Molecular Biology.
Kalama-Raptors
It’s no surprise that Associate Professor of Economics Chuck Stull, like most of his faculty colleagues, has a wide-ranging liberal arts-ish curiosity and sense of wonder. His biology and ornithology interests were piqued recently by a successful Red-Tailed Hawk predation of a Quad squirrel, which Stull managed to capture on camera.
In late December, the Kalamazoo Gazette carried an article about a Snowy Owl taking residence at the Battle Creek/Kalamazoo International Airport. Turns out, this year is an irruption of Snowy Owls, one of the largest on record. Often, Snowy Owls will take up residence near airports, which remind them of their tundra hunting grounds. The owl at the Kalamazoo airport died, most likely of starvation. Such an occurrence is sad, but not surprising. Up to 70 percent of the raptor offspring perish during their first winter—many from starvation. The hawk Professor Stull photographed may have better luck if he or she keeps in mind the campus’ squirrel-stocked Quad.